CAS 2488892-07-3

Benzamide, 2-[[5-bromo-2-[[4-[[[14-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12-tetraoxatetradec-1-yl]amino]sulfonyl]phenyl]amino]-4-pyrimidinyl]amino]-6-fluoro-

Description:

Benzamide, 2-[[5-bromo-2-[[4-[[[14-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12-tetraoxatetradec-1-yl]amino]sulfonyl]phenyl]amino]-4-pyrimidinyl]amino]-6-fluoro- is a complex organic compound characterized by its multi-functional structure, which includes a benzamide core and various substituents that contribute to its chemical properties. The presence of bromine and fluorine atoms indicates potential reactivity and influence on the compound's electronic properties. The sulfonamide and piperidine moieties suggest possible biological activity, making it of interest in medicinal chemistry. The compound's intricate structure, featuring multiple rings and functional groups, may also affect its solubility, stability, and interaction with biological targets. As a synthetic compound, it may be used in research settings to explore its pharmacological potential or as a lead compound in drug development. Its CAS number, 2488892-07-3, allows for precise identification in chemical databases and literature.

Formula: C₄₀H₄₃BrFN₉O₁₁S

Synonyms:

• Benzamide, 2-[[5-bromo-2-[[4-[[[14-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12-tetraoxatetradec-1-yl]amino]sulfonyl]phenyl]amino]-4-pyrimidinyl]amino]-6-fluoro-

TMX-2138

CAS: 2488892-07-3

TMX-2138 is a CDKs PROTAC degrader, with IC50 values of 8.7 nM for CDK1/cyclinB, 10.9 nM for CDK2/cyclinA, 7.0 nM for CDK5/p25, and 25.7 nM for CDK9/cyclinT1. It enhances the ubiquitination and degradation of CDKs and is utilized for ovarian cancer research.

Formula: C₄₀H₄₃BrFN₉O₁₁S

Color and Shape: Solid

Molecular weight: 956.791

Ref: TM-T204343