CAS 24939-03-5

Poly(I:C)

Description:

Poly(I:C), or polyinosinic-polycytidylic acid, is a synthetic double-stranded RNA molecule that serves as a potent immunostimulant. It is primarily recognized for its role in mimicking viral infections, thereby activating the immune response, particularly through the stimulation of toll-like receptors (TLRs), specifically TLR3. This activation leads to the production of various cytokines and interferons, enhancing the body's antiviral defenses. Poly(I:C) is often used in research and therapeutic applications, including vaccine development and cancer immunotherapy, due to its ability to induce a robust immune response. The substance is typically characterized by its high molecular weight and is soluble in water, making it suitable for various biological assays. Additionally, Poly(I:C) can be modified to improve its stability and efficacy, such as through the incorporation of chemical modifications that enhance its resistance to degradation by nucleases. Overall, Poly(I:C) is a valuable tool in immunology and therapeutic research, contributing to our understanding of immune mechanisms and potential treatment strategies.

Formula: (C₁₀H₁₃N₄O₈P)x·(C₉H₁₄N₃O₈P)x

InChI: InChI=1S/C10H13N4O8P.C9H14N3O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7-,8-/m11/s1

InChI key: InChIKey=ACEVNMQDUCOKHT-ZLOOHWKQSA-N

SMILES: O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=CN3)O[C@H](COP(=O)(O)O)[C@H]1O.O[C@H]1[C@@H](O[C@H](COP(=O)(O)O)[C@H]1O)N2C(=O)N=C(N)C=C2

Synonyms:

• 4-amino-1-(5-O-phosphonopentofuranosyl)pyrimidin-2(1H)-one - 9-(5-O-phosphonopentofuranosyl)-3,9-dihydro-6H-purin-6-one (1:1)
• 5'-Cytidylic Acid - 5'-Inosinic Acid (1:1)
• 5′-Cytidylic acid, homopolymer, complex with 5′-inosinic acid homopolymer (1:1)
• 5′-Cytidylic acid, polymers, complex with 5′-inosinic acid polymers (1:1)
• 5′-Inosinic acid homopolymer-5′-cytidylic acid homopolymer complex (1:1)
• 5′-Inosinic acid, homopolymer, complex with 5′-cytidylic acid homopolymer (1:1)
• 5′-Inosinic acid, polymers, complex with 5′-cytidylic acid polymers (1:1)
• NSC 120949
• NSC 123233
• NSC 128576
• Poly I:C
• Poly I:C Polyinosinicacid-polycytidylic acid
• Poly(C).poly(I)
• Poly(C:I)
• Poly(I)-poly(C)
• Poly(I).poly(C) complex
• Poly(cytidylic acid)-poly(inosinic acid)
• Poly(rI)-poly(rC)
• Poly(rI:rC)
• Polycytidylic-polyinosinic acid
• Polycytidysic acid
• Polyinosinate-polycytidylate complex
• Polyinosinate:polycytidylate
• Polyinosine-polycytidylic acid
• Polyinosinic acid-polycytidylic acid
• Polyinosinic acid:polycytidylic acid complex
• Polyinosinic-polycytidylic acid complex

5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acidhomopolymer (1:1)OTHER CA INDEX NAMES:5'-Cytidylic acid, homopolymer, complex with 5'-inosinic acidhomopolymer (1:1)

CAS: 24939-03-5

Formula: C₂₁H₃₅N₇O₁₆P₂

Purity: 90%

Color and Shape: Solid

Molecular weight: 703.4874

Ref: IN-DA00I4RN

Polyinosinic-polycytidylic acid

CAS: 24939-03-5

Polyinosinic-polycytidylic acid

Purity: ≥90%

Ref: 54-BUP06314

Polyinosinic acid-polycytidylic acid sodium salt

CAS: 24939-03-5

Ref: 7W-GC1062

Polyinosinic-polycytidylic acid

CAS: 24939-03-5

Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic double-stranded RNA (dsRNA) analog and an immunostimulant that acts as the most potent IFN inducer.

Formula: (C₁₀H₁₃N₄O₈P)x·(C₉H₁₄N₃O₈P)x

Purity: 90%

Color and Shape: Solid

Molecular weight: 671.4

Ref: TM-T23171

Poly(I:C) (~90%)

Controlled Product

CAS: 24939-03-5

Applications Poly(I:C) is a toll-like receptor 3 dsRNA inflammatory stimulant.
References Smith, G.A., et al.: PLoS One, 10, e0121072 (2015); Dauletbaev, N., et al.: J. Immunol., 195, 2829 (2015); Broering, R., et al.: J. Viral Hepatitis, 21, 480 (2014); Colapicchioni, V., et al.: J. Mater. Chem. B: Mater. Biol. Med., 3, 7408 (2015)

Formula: H₂(C₁₀H₁₁N₄O₈P)n·H₂(C₉H₁₂N₃O₈P)n

Purity: ~90%

Color and Shape: Neat

Molecular weight: 671.40

Ref: TR-P688075

Polyinosinic acid-polycytidylic acid, homopolymer (1:1)

CAS: 24939-03-5

Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure.PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes.We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.
For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'

Formula: (C₁₀H₁₃N₄O₈P)x•(C₉H₁₄N₃O₈P)x

Color and Shape: Powder

Ref: 3D-OP29952

Polyinosinic acid-polycytidylic acid, homopolymer (1:1)

CAS: 24939-03-5

Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure.PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes.We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.
For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'

Formula: (C₁₀H₁₃N₄O₈P)x•(C₉H₁₄N₃O₈P)x

Purity: (Hplc-Ms) Min. 95.0 Area-%

Ref: 3D-J-030005