CAS 249921-19-5

Anamorelin

Description:

Anamorelin is a synthetic small molecule classified as a ghrelin receptor agonist, primarily developed for its potential use in treating cachexia, a condition characterized by severe weight loss and muscle wasting often associated with chronic illnesses such as cancer. Its mechanism of action involves stimulating the growth hormone secretagogue receptor, which mimics the action of ghrelin, a hormone that promotes appetite and increases food intake. Anamorelin has been shown to enhance appetite and improve body weight in clinical settings. The substance is typically administered orally and has undergone various clinical trials to assess its efficacy and safety profile. In terms of chemical characteristics, Anamorelin has a specific molecular structure that contributes to its biological activity, and it is subject to standard pharmacological evaluations to determine its therapeutic potential and side effects. As with any pharmaceutical compound, its use should be guided by healthcare professionals, considering the individual patient's condition and overall treatment plan.

Formula: C₃₁H₄₂N₆O₃

InChI: InChI=1S/C31H42N6O3/c1-30(2,32)28(39)34-26(18-23-20-33-25-15-10-9-14-24(23)25)27(38)37-17-11-16-31(21-37,29(40)36(5)35(3)4)19-22-12-7-6-8-13-22/h6-10,12-15,20,26,33H,11,16-19,21,32H2,1-5H3,(H,34,39)/t26-,31-/m1/s1

InChI key: InChIKey=VQPFSIRUEPQQPP-MXBOTTGLSA-N

SMILES: C([C@@]1(C(N(N(C)C)C)=O)CN(C([C@@H](CC=2C=3C(NC2)=CC=CC3)NC(C(C)(C)N)=O)=O)CCC1)C4=CC=CC=C4

Synonyms:

• (3R)-1-(2-Methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide
• 3-Piperidinecarboxylic acid, 1-(2-methylalanyl-<span class="text-smallcaps">D</span>-tryptophyl)-3-(phenylmethyl)-, trimethylhydrazide, (3R)-
• 3-Piperidinecarboxylic acid, 1-[(2R)-2-[(2-amino-2-methyl-1-oxopropyl)amino]-3-(1H-indol-3-yl)-1-oxopropyl]-3-(phenylmethyl)-, 1,2,2-trimethylhydrazide, (3R)-
• Rc 1291
• Anamorelin
• 3-Piperidinecarboxylic acid, 1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-, trimethylhydrazide, (3R)-

Anamorelin

CAS: 249921-19-5

Anamorelin (ONO-7643) is a novel ghrelin receptor agonist (EC50: 0.74 nM in the FLIPR assay).

Formula: C₃₁H₄₂N₆O₃

Purity: 99.35% - 99.94%

Color and Shape: Solid

Molecular weight: 546.7

Ref: TM-T10319

Anamorelin

CAS: 249921-19-5

Formula: C₃₁H₄₂N₆O₃

Molecular weight: 546.72

Ref: 4Z-A-372001

Anamorelin Dihydrochloride

Controlled Product

CAS: 249921-19-5

Applications Anamorelin is a novel non-peptidic ghrelin mimetic and growth hormone secratogogue.
References Garcia, Jose M., et al.: Growth. Horm. IGF. Res., 19(3), 267-273 (2009)

Formula: C₃₁H₄₂N₆O₃

Color and Shape: Neat

Molecular weight: 546.70

Ref: TR-A617045

Anamorelin

CAS: 249921-19-5

Applications Anamorelin functions as a novel therapeutic options for cachexia and sarcopenia. Cancer cachexia and clinical therapeutic interventions.
References Molfino, A., et al.: Expert Opin. on Biol. Ther., 16, 1239 (2016); Crawford, Jeffrey: Curr. Opin. Clin. Nutr. Metab. Care, 19, 199 (2016)

Formula: C₃₁H₄₂N₆O₃

Color and Shape: White To Off-White

Molecular weight: 546.70

Ref: TR-A656510

Anamorelin-d6

Controlled Product

CAS: 249921-19-5

Applications Anamorelin-d6 is labelled Anamorelin (A617045) which is a novel non-peptidic ghrelin mimetic and growth hormone secratogogue.
References Garcia, Jose M., et al.: Growth. Horm. IGF. Res., 19(3), 267-273 (2009)

Formula: C₃₁D₆H₃₆N₆O₃

Color and Shape: Neat

Molecular weight: 552.741

Ref: TR-A617047

Anamorelin

CAS: 249921-19-5

Anamorelin is a peptide hormone that has been shown to have anti-cancer effects in animal models. It reduces the growth of cancer cells and inhibits their ability to form new blood vessels. Anamorelin also reduces the size of tumors and improves the symptoms of cancer patients. The drug can be applied topically or orally, and has been shown to be safe for use with other drugs during treatment trials. In vitro assays have shown that anamorelin inhibits the production of epidermal growth factor (EGF) by gland cells, which may account for its therapeutic effect. The drug can also improve metabolic disorders, such as obesity and diabetes mellitus type II.

Formula: C₃₁H₄₂N₆O₃

Purity: Min. 95%

Molecular weight: 546.7 g/mol

Ref: 3D-FA29568

3-Piperidinecarboxylic acid, 1-[(2R)-2-[(2-amino-2-methyl-1-oxopropyl)amino]-3-(1H-indol-3-yl)-1-oxopropyl]-3-(phenylmethyl)-, 1,2,2-trimethylhydrazide, (3R)-

CAS: 249921-19-5

Formula: C₃₁H₄₂N₆O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 546.7036

Ref: IN-DA002Q4E