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CAS 2502186-80-1

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  • KT-333 diammonium
    Targetmol
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    KT-333 diammonium

    CAS:
    <p>KT-333 diammonium functions as a molecular glue that targets and degrades the STAT3 protein. It selectively mediates the degradation of STAT3 via the ubiquitin-proteasome pathway by attaching to STAT3 and the E3 ubiquitin ligase von Hippel-Lindau protein (VHL). This compound exhibits strong specificity in degrading STAT3 and demonstrates significant antitumor activity. KT-333 diammonium is applicable in researching hematologic malignancies, including large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL).</p>
    Formula:C60H80ClN12O14PS
    Color and Shape:Solid
    Molecular weight:1291.84

    Ref: TM-T88365