CAS 250584-13-5

L-Valinamide,N-[(phenylmethoxy)carbonyl]-L-a-aspartyl-L-a-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-(9CI)

Description:

L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl] is a complex organic compound characterized by its specific amino acid derivatives and functional groups. This substance features a valinamide backbone, which is an amino acid derivative, and is modified with a phenylmethoxycarbonyl group, enhancing its stability and solubility. The presence of aspartyl and glutamyl residues indicates that it is a peptide-like structure, potentially involved in biological processes or pharmaceutical applications. The compound also contains a chloro-oxopropyl moiety, which may contribute to its reactivity and biological activity. Its CAS number, 250584-13-5, allows for precise identification in chemical databases. Overall, this compound's unique structure suggests potential utility in medicinal chemistry, particularly in the development of peptide-based therapeutics or as a biochemical probe, although specific applications would depend on further research into its properties and interactions.

Formula: C₂₇H₃₅ClN₄O₁₂

Synonyms:

• Z-Asp-Glu-Val-Asp-Chloromethylketone
• Z-Asp-Glu-Val-Asp-Cmk
• Z-Devd-Cmk

Z-Asp-Glu-Val-Asp-chloromethylketone

CAS: 250584-13-5

Z-Asp-Glu-Val-Asp-chloromethylketone is a reactive compound that inhibits the activity of proteases and induces neuronal death. Z-Asp-Glu-Val-Asp-chloromethylketone has been shown to induce necrotic cell death in malignant brain cells and has neurotrophic properties. It also causes mitochondrial membrane depolarization, which leads to mitochondrial cytochrome c release and subsequent apoptosis. The reaction mechanism is still unclear but it may involve hydrogen bonding between the ketone group and the amide nitrogen atom of the aspartate residue.

Formula: C₂₇H₃₅ClN₄O₁₂

Purity: Min. 95%

Molecular weight: 643.04 g/mol

Ref: 3D-FA111069

Z-DEVD-CMK

CAS: 250584-13-5

Z-DEVD-CMK irreversibly inhibits various cathepsins in vitro [1].

Formula: C₂₇H₃₅ClN₄O₁₂

Color and Shape: Solid

Molecular weight: 643.04

Ref: TM-T80660