CAS 2506367-95-7

1-Pyrrolidineacetamide, α-methyl-2,5-dioxo-N-(phenylmethyl)-, (αR)-

Description:

1-Pyrrolidineacetamide, α-methyl-2,5-dioxo-N-(phenylmethyl)-, (αR)- is a chemical compound characterized by its unique structural features, which include a pyrrolidine ring and an acetamide functional group. This compound is likely to exhibit properties typical of amides, such as moderate solubility in polar solvents and potential for hydrogen bonding due to the presence of the amide group. The α-methyl and phenylmethyl substituents contribute to its steric and electronic properties, potentially influencing its reactivity and interactions with biological targets. The presence of the dioxo moiety suggests that it may participate in various chemical reactions, including those involving nucleophiles or electrophiles. As a chiral compound, it may exhibit enantiomeric differences in biological activity, which is significant in pharmacology and medicinal chemistry. Overall, the characteristics of this compound make it of interest in research areas such as drug development and synthetic chemistry, although specific applications would depend on further studies and evaluations of its biological activity and safety profile.

Formula: C₁₄H₁₆N₂O₃

Synonyms:

• (R)-N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide
• 1-Pyrrolidineacetamide, α-methyl-2,5-dioxo-N-(phenylmethyl)-, (αR)-
• (R)-AS-1

(R)-AS-1

CAS: 2506367-95-7

(R)-AS-1 is a selective positive allosteric modulator of excitatory amino acid transporter 2 (EAAT2), with an EC50 of 11 nM. At doses of 60 and 90 mg/kg, (R)-AS-1 enhances spontaneous locomotor activity in mice. It demonstrates anticonvulsant properties in mouse seizure models induced by maximal electroshock (MES), pentylenetetrazole (PTZ), or electric current stimulation (32 or 44 mA), with ED50 values of 66.3, 36.3, 15.6, and 41.6 mg/kg, respectively. This compound is applicable in neurological disease research.

Formula: C₁₄H₁₆N₂O₃

Color and Shape: Solid

Molecular weight: 260.29

Ref: TM-T203260