CAS 250695-65-9

1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolylglycine

Description:

1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolylglycine, commonly referred to as Fmoc-Pro-Gly, is a chemical compound used primarily in peptide synthesis and research. It features a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is widely utilized in solid-phase peptide synthesis due to its stability under basic conditions and ease of removal under acidic conditions. The compound consists of the amino acids proline and glycine, which contribute to its structural and functional properties. The presence of the Fmoc group enhances the solubility of the compound in organic solvents, making it suitable for various synthetic applications. Additionally, the proline residue introduces a unique conformational flexibility, while glycine, being the simplest amino acid, provides a minimal steric hindrance. This compound is typically characterized by its molecular weight, solubility in organic solvents, and specific reactivity patterns during peptide coupling reactions. Overall, Fmoc-Pro-Gly is a valuable intermediate in the synthesis of peptides and proteins in biochemical research and pharmaceutical development.

Formula: C₂₂H₂₂N₂O₅

InChI: InChI=1S/C22H22N2O5/c25-20(26)12-23-21(27)19-10-5-11-24(19)22(28)29-13-18-16-8-3-1-6-14(16)15-7-2-4-9-17(15)18/h1-4,6-9,18-19H,5,10-13H2,(H,23,27)(H,25,26)/t19-/m0/s1

InChI key: InChIKey=YINDOSYVRZADBY-IBGZPJMESA-N

SMILES: C(OC(=O)N1[C@H](C(NCC(O)=O)=O)CCC1)C2C=3C(C=4C2=CC=CC4)=CC=CC3

Synonyms:

• 2-[[(2S)-1-[[(9H-Fluoren-9-yl)methoxy]carbonyl]pyrrolidin-2-yl]formamido]acetic acid
• 2-[[(2S)-1-(9H-Fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carbonyl]amino]acetic acid
• Glycine, 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-
• 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolylglycine

Fmoc-Pro-Gly-OH

CAS: 250695-65-9

Bachem ID: 4003184.

Formula: C₂₂H₂₂N₂O₅

Purity: 99.2%

Color and Shape: White

Molecular weight: 394.43

Ref: 01-4003184

N-α-(9-Fluorenylmethyloxycarbonyl)-L-prolinyl-glycin

CAS: 250695-65-9

Formula: C₂₂H₂₂N₂O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 394.4205

Ref: IN-DA00VQNL

Fmoc-Pro-Gly-OH

CAS: 250695-65-9

Fmoc-Pro-Gly-OH

Purity: ≥95%

Molecular weight: 394.42g/mol

Ref: 54-OR36390

Fmoc-Pro-Gly-OH

CAS: 250695-65-9

Fmoc-Pro-Gly-OH is an antimicrobial agent that binds to bacterial cell walls and prevents the bacteria from assembling. It has a conformation that mimics the structure of thioether antibiotics, which are unilamellar and assembled. Fmoc-Pro-Gly-OH inhibits the pyrophosphate binding site, preventing the synthesis of ATP in bacteria. This drug also has affinity for alkene binders, which may be due to its structural similarity to these compounds.

Formula: C₂₂H₂₂N₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 394.42 g/mol

Ref: 3D-FF111294

Fmoc-Pro-Gly-OH

CAS: 250695-65-9

Formula: C₂₂H₂₂N₂O₅

Purity: 95%

Molecular weight: 394.427

Ref: 10-F492875