CAS 250737-12-3

PRAVASTATIN IMPURITY A

Description:

Pravastatin Impurity A, with the CAS number 250737-12-3, is a chemical compound associated with the pharmaceutical agent pravastatin, which is used primarily for lowering cholesterol levels. As an impurity, it may arise during the synthesis or formulation of pravastatin and is typically characterized by its specific molecular structure and properties. Impurities like this can affect the efficacy and safety of the final pharmaceutical product, making their identification and quantification crucial in drug development and quality control. The characteristics of Pravastatin Impurity A may include its molecular weight, solubility in various solvents, and stability under different conditions. Analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry are often employed to detect and quantify such impurities. Regulatory guidelines require that impurities be well-characterized to ensure that they do not adversely affect the therapeutic outcomes or pose safety risks to patients. Understanding the properties of impurities is essential for maintaining the integrity of pharmaceutical formulations.

Formula: C₂₃H₃₆O₇

Synonyms:

• 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, (βR,δR,1S,2S,6R,8S,8aR)-
• 6'-Epipravastatin
• PRAVASTATIN IMPURITY A
• Sodium (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6R,8S,8aR)-6- hydroxy-2-methyl-8-[[(2S)-2-methylbutanoyl]oxy]- 1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid
• Pravastatin impurity A (Y0000223)
• Pravastatin impurity A CRS
• (3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6R,8S,8aR)-6-hydroxy-2-methyl-8-[[(2S)-2-methylbutanoyl]oxy]-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid

PRAVASTATIN IMPURITY A CRS

CAS: 250737-12-3

PRAVASTATIN IMPURITY A CRS

Formula: C₂₃H₃₆O₇

Molecular weight: 424.5277

Ref: 41-Y0000223

Pravastatin impurity A

CAS: 250737-12-3

Pravastatin impurity A

Formula: C₂₃H₃₆O₇

Color and Shape: Off-White

Molecular weight: 424.5277

Ref: 47-1030

Pravastatin impurity A

CAS: 250737-12-3

Pravastatin impurity A is a synthetic impurity found in the drug product pravastatin. It is not listed as an impurity in the pharmacopoeia and has no CAS number assigned to it. This impurity is a yellow crystalline solid. It has been shown to be metabolized by cytochrome P450 3A4/5, CYP2C8, CYP2C9, and CYP3A4 isoforms with half-lives of 1.6 hours, 2.2 hours, 3.7 hours, and 6.1 hours respectively.

Formula: C₂₃H₃₆O₇

Purity: Min. 95%

Molecular weight: 424.5 g/mol

Ref: 3D-IP182103