CAS 250780-40-6

(3R,4R,5R,6R)-3,4,5-trihydroxy-6-[2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propyl-benzimidazol-1-yl]methyl]phenyl]benzoyl]oxy-tetrahydropyran-2-carboxylic acid

Description:

The chemical substance with the name "(3R,4R,5R,6R)-3,4,5-trihydroxy-6-[2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propyl-benzimidazol-1-yl]methyl]phenyl]benzoyl]oxy-tetrahydropyran-2-carboxylic acid" and CAS number "250780-40-6" is a complex organic compound characterized by multiple functional groups, including hydroxyl (-OH) groups and a carboxylic acid (-COOH) moiety. Its structure features a tetrahydropyran ring, which contributes to its cyclic nature and potential stereochemistry, indicated by the specified R configurations. The presence of benzimidazole derivatives suggests potential biological activity, possibly related to pharmacological applications. The compound's intricate structure may influence its solubility, stability, and reactivity, making it of interest in medicinal chemistry and drug development. Additionally, the presence of multiple aromatic rings may enhance its interaction with biological targets, potentially leading to specific therapeutic effects. Overall, this compound exemplifies the complexity often found in bioactive molecules, which can be crucial for their function and efficacy in biological systems.

Formula: C₃₉H₃₈N₄O₈

InChI: InChI=1/C39H38N4O8/c1-4-9-30-41-31-21(2)18-24(36-40-27-12-7-8-13-28(27)42(36)3)19-29(31)43(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)38(49)51-39-34(46)32(44)33(45)35(50-39)37(47)48/h5-8,10-19,32-35,39,44-46H,4,9,20H2,1-3H3,(H,47,48)/t32-,33-,34-,35?,39-/m1/s1

SMILES: CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)c1ccccc1C(=O)O[C@@H]1[C@@H]([C@@H]([C@H](C(C(=O)O)O1)O)O)O)c1nc2ccccc2n1C

Synonyms:

• TelMisartan Glucuronide
• 1-[4'-[(1',4-dimethyl-2-propyl[2',6-bi-1H-benzimidazol]-1-yl)methyl][1,1'-biphenyl]-2-carboxylate] -D-Glucopyranuronic acid,
• Telmisartan Acyl--D-glucuronide
• Telmisartan-acyl-beta-D-glucuronide min. 95%
• 1-[4'-[(1',4-DiMethyl-2-propyl[2',6-bi-1H-benziMidazol]-1-yl)Methyl][1,1'-biphenyl]-2-carboxylate]
• Telmisartan acyl-β-D-glucuronide ,98%

β-D-Glucopyranuronic acid, 1-[4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylate]

CAS: 250780-40-6

Formula: C₃₉H₃₈N₄O₈

Color and Shape: Solid

Molecular weight: 690.741

Ref: IN-DA002QEM

Telmisartan Acyl Glucuronide

CAS: 250780-40-6

Formula: C₃₉H₃₈N₄O₈

Color and Shape: White To Off-White Solid

Molecular weight: 690.76

Ref: 4Z-T-132

Telmisartan-acyl-β-D-glucuronide

CAS: 250780-40-6

Telmisartan-acyl-β-D-glucuronide

Purity: >95%

Molecular weight: 690.74g/mol

Ref: 54-BICL4201

Telmisartan acyl-b-D-glucuronide

CAS: 250780-40-6

Ref: 7W-GC3131

Telmisartan-d3 Acyl-β-D-glucuronide

Controlled Product

CAS: 250780-40-6

Applications Labelled Telmisartan Acyl-β-D-glucuronide (T017010). Telmisartan Acyl-β-D-glucuronide is a metabolite of Telmisartan (T017000).
References Abe, T., et al.: J. Biol. Chem., 274, 17159 (1999), Hirano, M., et al.: Drug Metab. Dispos., 34, 1229 (2006),

Formula: C₃₉H₃₅D₃N₄O₈

Color and Shape: Neat

Molecular weight: 693.76

Ref: TR-T017012

Telmisartan Acyl-β-D-glucuronide

Controlled Product

CAS: 250780-40-6

Applications Telmisartan Acyl-β-D-glucuronide is a metabolite of Telmisartan (T017000).
References Abe, T., et al.: J. Biol. Chem., 274, 17159 (1999), Hirano, M., et al.: Drug Metab. Dispos., 34, 1229 (2006),

Formula: C₃₉H₃₈N₄O₈

Color and Shape: White To Off-White

Molecular weight: 690.74

Ref: TR-T017010

Telmisartan acyl-b-D-glucuronide

CAS: 250780-40-6

Telmisartan acyl-b-D-glucuronide is a drug metabolite that is formed by the conjugation of telmisartan with glucuronic acid. Telmisartan acyl-b-D-glucuronide is activated in vivo and reversibly inhibits the enzyme creatine kinase, which is involved in the metabolism of creatine to creatinine. The effective dose for this compound has been shown to be 10 mg/kg (orally) in humans. Telmisartan acyl-b-D-glucuronide has been shown to be an at1 receptor antagonist and may have some antihypertensive effects via modulation of ion channels. This drug also appears to have some proliferative effects on cells that are inhibited by radiation.

Formula: C₃₉H₃₈N₄O₈

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 690.74 g/mol

Ref: 3D-MT07380

Telmisartan Acyl-β-D-glucuronide

CAS: 250780-40-6

Formula: C₃₉H₃₈N₄O₈

Molecular weight: 690.75

Ref: ST-EA-CP-T4045

Telmisartan Acyl-β-D-Glucuronide

CAS: 250780-40-6

Telmisartan acyl-β-D-glucuronide is a major metabolite of the angiotensin II receptor antagonist telmisartan .

Formula: C₃₉H₃₈N₄O₈

Color and Shape: Solid

Molecular weight: 690.753

Ref: TM-T35865