CAS 251111-30-5

Beloranib

Description:

Beloranib, also known by its chemical name, is a synthetic compound that has garnered attention for its potential therapeutic applications, particularly in the field of obesity and metabolic disorders. It functions as a potent inhibitor of the enzyme methionine aminopeptidase 2 (MetAP2), which plays a crucial role in protein synthesis and cellular processes. By inhibiting this enzyme, Beloranib can influence pathways related to weight regulation and fat metabolism. The substance is characterized by its specific molecular structure, which includes various functional groups that contribute to its biological activity. Beloranib has undergone clinical trials to assess its efficacy and safety in humans, particularly for weight loss in obese patients. However, its development has faced challenges, leading to a reevaluation of its therapeutic potential. As with many investigational drugs, understanding the pharmacokinetics, pharmacodynamics, and potential side effects is essential for determining its viability as a treatment option. Overall, Beloranib represents a noteworthy example of targeted therapy in metabolic disease management.

Formula: C₂₉H₄₁NO₆

InChI: InChI=1S/C29H41NO6/c1-20(2)7-13-24-28(3,36-24)27-26(32-6)23(15-16-29(27)19-34-29)35-25(31)14-10-21-8-11-22(12-9-21)33-18-17-30(4)5/h7-12,14,23-24,26-27H,13,15-19H2,1-6H3/b14-10+/t23-,24-,26-,27-,28+,29+/m1/s1

InChI key: InChIKey=ZEZFKUBILQRZCK-MJSCXXSSSA-N

SMILES: C[C@@]1([C@@]2([C@@]3(CO3)CC[C@@H](OC(/C=C/C4=CC=C(OCCN(C)C)C=C4)=O)[C@H]2OC)[H])[C@@H](CC=C(C)C)O1

Synonyms:

• 2-Propenoic acid, 3-[4-[2-(dimethylamino)ethoxy]phenyl]-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester, (2E)-
• 2-Propenoic acid, 3-[4-[2-(dimethylamino)ethoxy]phenyl]-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester, (2E)-
• 6-O-[3-[4-[2-(Dimethylamino)ethoxy]phenyl]-2(E)-propenoyl]fumagillol
• Beloranib
• Ckd-732
• O-[4-(2-Dimethylaminoethoxy)-trans-cinnamoyl]fumagillol
• Zgn 440

Beloranib (>85%)

Controlled Product

CAS: 251111-30-5

Applications Beloranib is a pharmaceutical drug that is currently being evaluated through biological studies for its potential to combat obesity.
References George, M., et al.: J. Cardiovasc. Pharm. T., 19, 65 (2014); Kremers, S., et al.: Obes. Rev., 11, 371 (2010);

Formula: C₂₉H₄₁NO₆

Purity: >85%

Color and Shape: Neat

Molecular weight: 499.64

Ref: TR-B131280

Beloranib

Controlled Product

CAS: 251111-30-5

Inhibitor of methionine aminopeptidase METAP2

Formula: C₂₉H₄₁NO₆

Purity: Min. 95%

Molecular weight: 499.64 g/mol

Ref: 3D-FB61548

Beloranib

CAS: 251111-30-5

Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.

Formula: C₂₉H₄₁NO₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 499.64

Ref: TM-T19871