CAS 251293-28-4

L-Valine, L-a-glutamyl-L-threonyl-L-prolyl-L-a-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-,cyclic (5®10)-disulfide

Description:

L-Valine, L-a-glutamyl-L-threonyl-L-prolyl-L-a-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-, cyclic (5®10)-disulfide, identified by CAS number 251293-28-4, is a cyclic peptide composed of multiple amino acids. This compound features a cyclic structure formed by a disulfide bond between two cysteine residues, which contributes to its stability and unique properties. The presence of various amino acids, including valine, glutamate, threonine, proline, aspartate, cysteine, phenylalanine, tryptophan, lysine, and tyrosine, suggests that it may exhibit diverse biological activities, potentially influencing protein interactions and cellular functions. The cyclic nature of the peptide can enhance its resistance to enzymatic degradation, making it a candidate for therapeutic applications. Additionally, the specific arrangement of amino acids may impart unique conformational characteristics, affecting its solubility, binding affinity, and overall bioactivity. Further studies would be necessary to elucidate its precise functions and potential uses in biochemistry or medicine.

Formula: C₆₄H₈₅N₁₃O₁₈S₂

Synonyms:

• 1:PN: JP2002087982 PAGE: 2 claimed protein
• 47: PN: WO0031265 SEQID: 3 claimedprotein
• Human urotensin II
• Urotensin II (human)
• H-Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH (Disulfide bond)

Urotensin II (human)

CAS: 251293-28-4

Urotensin II is a vasoactive somatostatin-like cyclic peptide, which has long been regarded as a peptide exclusively produced by the urophysis of teleost fish. U-II has also been cloned from man. It was found to be the most potent mammalian vasoconstrictor identified so far. Furthermore, as urotensin II immunoreactivity was also found within central nervous system and endocrine tissues, it may have additional activities.

Formula: C₆₄H₈₅N₁₃O₁₈S₂

Purity: ≥ 95%

Color and Shape: White Powder

Molecular weight: 1388.59

Ref: 01-4029364

Urotensin II (114-124), human

CAS: 251293-28-4

Human Urotensin II (114-124) is an 11-amino acid peptide with vasoconstrictor properties and agonizes GPR14.

Formula: C₆₄H₈₅N₁₃O₁₈S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 1388.57

Ref: TM-TP1737

Urotensin II (Human)

CAS: 251293-28-4

A potent vasoconstrictor, available in the hydrochloride form with disulfide bonds between Cys5-Cys10 and as a 0.5mg vial.
Urotensin II (UT-II) is a peptide that is found in humans and other vertebrates and is involved in biological systems such as the nervous, endocrine, cardiovascular and renal.
Like that of urotensin II-related peptide, urotensin II contains the hexapeptide -CYS-TYR-LYS-TRP-PHE-CYS- known as the core and this is crucial to its biological function. Urotensin II can also increase the concentration of intercellular calcium through binding to its G protein coupled receptor: urotensin-II receptor which causes the activation of Protein kinase C followed by the activation of Phospholipase C.
UT-II is widely distributed throughout the body, with highest concentrations found in the cardiovascular system, particularly in the heart and blood vessels. UT-II has been shown to have a wide range of physiological effects in humans, including vasoconstriction, modulation of blood pressure, and stimulation of the release of aldosterone and vasopressin. 
In addition to its physiological effects, UT-II has also been implicated in the pathogenesis of various cardiovascular and metabolic disorders, including hypertension, heart failure, and diabetes. Inhibition of UT-II signaling has been suggested as a potential therapeutic target for these conditions.

Formula: C₆₄H₈₅N₁₃O₁₈S₂

Purity: Min. 95%

Molecular weight: 1,388.6 g/mol

Ref: 3D-PUT-4365-V