CAS 251647-51-5

5'-O-Dmtr- 2'-O-(2-Methoxyethyl)-Uridine

Description:

5'-O-Dmtr-2'-O-(2-Methoxyethyl)-Uridine is a modified nucleoside that features several distinctive characteristics. It is a derivative of uridine, where the 5' position is protected by a dimethoxytrityl (Dmtr) group, enhancing its stability and facilitating its use in oligonucleotide synthesis. The 2'-O-(2-Methoxyethyl) modification provides increased resistance to nucleases, improving the stability of RNA molecules in biological systems. This modification also enhances the solubility and overall pharmacokinetic properties of the nucleoside. The compound is typically utilized in the synthesis of RNA oligonucleotides for research and therapeutic applications, particularly in the development of antisense oligonucleotides and RNA interference technologies. Its unique structural features contribute to its effectiveness in various biochemical and molecular biology applications, making it a valuable tool in the field of nucleic acid chemistry.

Synonyms:

• 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-Methoxyethyl)-Uridine

1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

CAS: 251647-51-5

Formula: C₃₃H₃₆N₂O₉

Purity: 96%

Molecular weight: 604.6469

Ref: IN-DA002QPN

1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

CAS: 251647-51-5

1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Purity: 96%

Ref: 54-OR1038764

5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)  uridine

CAS: 251647-51-5

5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl) uridine is a Nucleoside Derivative - 2'-Modified nucleoside; Protected nucleoside with NH2/OH open; Ready for

Formula: C₃₃H₃₆N₂O₉

Color and Shape: Solid

Molecular weight: 604.65

Ref: TM-TNU1093

1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

CAS: 251647-51-5

Purity: 96%

Molecular weight: 604.6560059

Ref: 10-F605785

5'-O-DMT-2'-O-(2-methoxyethyl)uridine

CAS: 251647-51-5

5'-O-DMT-2'-O-(2-methoxyethyl)uridine is a modified nucleoside that is an antiviral and anticancer agent. It was first synthesized in the early 1980s, and has been shown to be active against a variety of viruses, such as herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), hepatitis B virus (HBV), and Epstein-Barr virus (EBV). 5'-O-DMT-2'-O-(2-methoxyethyl)uridine inhibits the growth of cancer cells by interfering with DNA synthesis. This drug also has been shown to be an activator for DNA polymerases and is used as a building block for antiretroviral drugs.

Formula: C₃₃H₃₆N₂O₉

Purity: Min. 95%

Molecular weight: 604.65 g/mol

Ref: 3D-ND76851