CAS 251647-55-9

Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

Description:

Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a complex nucleoside derivative characterized by its unique structural modifications that enhance its stability and reactivity. This compound features a guanosine backbone, which is a purine nucleoside, modified at the 5′ and 2′ positions with various functional groups, including methoxyphenyl and cyanoethyl phosphoramidite moieties. These modifications are designed to improve the compound's performance in applications such as oligonucleotide synthesis and gene therapy. The presence of the phosphoramidite group allows for efficient coupling reactions in the synthesis of oligonucleotides, while the methoxy groups may contribute to solubility and stability in biological environments. Overall, this compound exemplifies the intricate design of nucleoside analogs aimed at enhancing therapeutic efficacy and stability in nucleic acid-based applications.

Formula: C₄₇H₆₀N₇O₁₀P

InChI: InChI=1S/C47H60N7O10P/c1-30(2)43(55)51-46-50-42-39(44(56)52-46)49-29-53(42)45-41(60-27-26-57-7)40(64-65(62-25-13-24-48)54(31(3)4)32(5)6)38(63-45)28-61-47(33-14-11-10-12-15-33,34-16-20-36(58-8)21-17-34)35-18-22-37(59-9)23-19-35/h10-12,14-23,29-32,38,40-41,45H,13,25-28H2,1-9H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,65?/m1/s1

InChI key: InChIKey=LADCDGNEBIQAAU-SBCRAQIVSA-N

SMILES: C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OCCOC)[C@@H](O1)N2C3=C(N=C2)C(=O)N=C(NC(C(C)C)=O)N3)(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6

Synonyms:

• 2'-O-Methyl-N2-Isobutyryl-5'-O-DMT-Guanosine-3'-CE-Phosphoramidite
• Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
• Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• 22: PN: US20030198965 PAGE: 20 claimed sequence
• 18: PN: US20030211606 PAGE: 20 claimed sequence
• 17: PN: US20030212017 PAGE: 20 claimed sequence
• DMT-2'-O-MOE-G(iBu)-CE-Phosphoramidite
• 5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite
• N2-isobutyryl-5'-O-DMT-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite
• 5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine 3'-CE phosphoramidite
• N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-O- methoxyethyl-guanosine-3'-cyanoethyl Phosphoramidite
• DMT-2μ-O-Me-rG(ib) amidite
• 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O-methylguanosine-3'-(2-cyanoethyl diisopropylphosphoramidite)
• 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• 2'-O-MOE-G(iBu)-CE Phosphoramidite
• 2'-O-MOE-rG(ibu) Phosphoramidite
• 5’-O-(4,4’-Dimethoxy-trityl)-N2-iso-butyroyl-2’-O-(2-methoxyethyl)guanosine-3’-O-[(2-cyanoethyl)(N,N-diisopropyl)]-phosphoramidite
• 5'-O-DMT-N2-isobutyryl-2'-O-?methoxyethylguanosine 3'-CE phosphoramidite
• 2'-MOE-G(iBu)-3'-phosphoramidite
• 2'-O-MOE-ibu-G Phosphoramidite
• DMT-2'-O-MOE-G(iBu)-CEP

DMT-2μ-O-Me-rG(ib) amidite

CAS: 251647-55-9

Formula: C₄₇H₆₀N₇O₁₀P

Purity: 95%

Color and Shape: Solid

Molecular weight: 913.9940

Ref: IN-DA00BHUW

5''-O-DMT-N2-isobutyryl-2''-O-methylguanosine 3''-CE phosphoramidite

CAS: 251647-55-9

Ref: 7W-GN5960

Dmt-2'O-Moe-Rg(Ib) Phosphoramidite

CAS: 251647-55-9

Dmt-2'O-Moe-Rg(Ib) Phosphoramidite

Purity: 98%

Molecular weight: 913.99g/mol

Ref: 54-OR1029712

DMT-2'-O-MOE-rG(Ib) Phosphoramidite

CAS: 251647-55-9

Formula: C₄₇H₆₀N₇O₁₀P

Purity: >95.0%(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 914.01

Ref: 3B-M3371

2'-MOE-G(iBu)-3'-phosphoramidite

CAS: 251647-55-9

2'-MOE-G(iBu)-3'-phosphoramidite is a Nucleoside Phosphoramidite;Nucleoside Derivative - 2'-Modified nucleoside;.

Formula: C₄₇H₆₀N₇O₁₀P

Color and Shape: Solid

Molecular weight: 913.99

Ref: TM-TNU0960

5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite

CAS: 251647-55-9

Nucleoside phosphoramidites are used in the synthesis of oligonucleotides. Using a chemical approach allows quick and inexpensive access to custom-made oligonucleotides of the desired sequence. Enzymatic synthesis proceeds in a 5’ to 3’ direction, however the chemical synthesis is usually performed in the opposite direction. 5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite, also known as DMT-2'-O-MOE-G(iBu)-CEP, is a modified guanosine with a 2’-O-(2-methoxyethyl) group, these have been used in the synthesis of oligonucleotides as antisense drugs.

Formula: C₄₇H₆₀N₇O₁₀P

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 913.99 g/mol

Ref: 3D-PD63448

DMT-2’O-MOE-rG(ib) Phosphoramidite

CAS: 251647-55-9

Purity: 95%

Molecular weight: 914.01

Ref: 10-F986336