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CAS 251647-55-9

:

Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

Description:
Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a complex nucleoside derivative characterized by its unique structural modifications that enhance its stability and reactivity. This compound features a guanosine backbone, which is a purine nucleoside, modified at the 5′ and 2′ positions with various functional groups, including methoxyphenyl and cyanoethyl phosphoramidite moieties. These modifications are designed to improve the compound's performance in applications such as oligonucleotide synthesis and gene therapy. The presence of the phosphoramidite group allows for efficient coupling reactions in the synthesis of oligonucleotides, while the methoxy groups may contribute to solubility and stability in biological environments. Overall, this compound exemplifies the intricate design of nucleoside analogs aimed at enhancing therapeutic efficacy and stability in nucleic acid-based applications.
Formula:C47H60N7O10P
InChI:InChI=1S/C47H60N7O10P/c1-30(2)43(55)51-46-50-42-39(44(56)52-46)49-29-53(42)45-41(60-27-26-57-7)40(64-65(62-25-13-24-48)54(31(3)4)32(5)6)38(63-45)28-61-47(33-14-11-10-12-15-33,34-16-20-36(58-8)21-17-34)35-18-22-37(59-9)23-19-35/h10-12,14-23,29-32,38,40-41,45H,13,25-28H2,1-9H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,65?/m1/s1
InChI key:InChIKey=LADCDGNEBIQAAU-SBCRAQIVSA-N
SMILES:C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OCCOC)[C@@H](O1)N2C3=C(N=C2)C(=O)N=C(NC(C(C)C)=O)N3)(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6
Synonyms:
  • 2'-O-Methyl-N2-Isobutyryl-5'-O-DMT-Guanosine-3'-CE-Phosphoramidite
  • Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
  • 22: PN: US20030198965 PAGE: 20 claimed sequence
  • 18: PN: US20030211606 PAGE: 20 claimed sequence
  • 17: PN: US20030212017 PAGE: 20 claimed sequence
  • DMT-2'-O-MOE-G(iBu)-CE-Phosphoramidite
  • 5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite
  • N2-isobutyryl-5'-O-DMT-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite
  • 5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine 3'-CE phosphoramidite
  • See more synonyms
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