Description:Fmoc-His(3-Me)-OH, also known as 9-fluorenylmethoxycarbonyl-L-histidine(3-methyl), is a protected form of the amino acid histidine, which is commonly used in peptide synthesis. The Fmoc (9-fluorenylmethoxycarbonyl) group serves as a protective group for the amino functionality, allowing for selective reactions at the carboxyl end of the amino acid during peptide assembly. The presence of the 3-methyl substitution on the histidine side chain alters its properties, potentially influencing the peptide's overall structure and function. This compound is typically white to off-white in appearance and is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF), but less soluble in water. Its stability under standard laboratory conditions makes it suitable for various applications in organic synthesis and biochemistry. The CAS number 252049-16-4 uniquely identifies this compound, facilitating its recognition in chemical databases and literature. Overall, Fmoc-His(3-Me)-OH is a valuable building block in the synthesis of peptides with specific functional characteristics.
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