CAS 252198-49-5
:Tertiapin-Q
Description:
Tertiapin-Q is a peptide derived from the venom of the honeybee (Apis mellifera) and is known for its selective inhibition of certain potassium ion channels, particularly the inwardly rectifying potassium channels (KIR). This characteristic makes it a valuable tool in neuropharmacology and cardiac research, as it can modulate cellular excitability and influence various physiological processes. Tertiapin-Q is composed of a specific sequence of amino acids that contributes to its unique binding properties and selectivity. The substance is typically studied for its potential therapeutic applications, including its role in understanding ion channel function and its implications in conditions such as arrhythmias and neurological disorders. Additionally, Tertiapin-Q's structure and function have made it a subject of interest in the development of novel drugs targeting ion channels. As a peptide, it is generally soluble in aqueous solutions and may require specific conditions for stability and storage.
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Tertiapin Q
CAS:<p>Tertiapin Q is a peptide inhibitor, a derivative of tertiapin, from honeybee venom (specifically Apis mellifera). This peptide acts by specifically blocking certain potassium channels, namely Kir1.1 and Kir3.1/3.4. The mode of action involves binding to the outer mouth of the potassium channel pore, effectively inhibiting ion flow through these channels. Tertiapin Q varies from native tertiapin by one amino acid, where a methionine residue is replaced with a glutamine residue. This means that unlike native TPN, TPN(Q) is not air oxidizable.Tertiapin : H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Met-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2Tertiapin Q: H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2Tertiapin Q is used in electrophysiological research to study the role and regulation of inward-rectifier potassium channels in various physiological and pathological processes. Its specificity and potency make it an invaluable tool in the exploration of renal physiology and cardiac cellular activity, as well as in neuroscience research for understanding neuronal excitability.</p>Formula:C106H175N35O24S4Purity:Min. 95%Molecular weight:2,452.05 g/mol
