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CAS 252260-02-9

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Posizolid

Description:
Posizolid is a synthetic oxazolidinone antibiotic that has been investigated for its potential use in treating infections caused by Gram-positive bacteria, including multidrug-resistant strains. It exhibits a mechanism of action similar to that of linezolid, inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit. Posizolid is characterized by its broad-spectrum activity against various pathogens, including Staphylococcus aureus and Streptococcus pneumoniae. Its chemical structure includes a bicyclic oxazolidinone core, which contributes to its antibacterial properties. Posizolid has shown promise in preclinical and clinical studies, demonstrating favorable pharmacokinetics and a lower propensity for developing resistance compared to other antibiotics. Additionally, it has been evaluated for its safety profile, with studies indicating a tolerable side effect profile. However, as of the latest data, it is essential to note that further research and clinical trials are necessary to fully establish its efficacy and safety for widespread clinical use.
Formula:C21H21F2N3O7
InChI:InChI=1/C21H21F2N3O7/c22-15-7-13(26-9-14(33-21(26)30)11-31-18-3-6-32-24-18)8-16(23)19(15)12-1-4-25(5-2-12)20(29)17(28)10-27/h1,3,6-8,14,17,27-28H,2,4-5,9-11H2/t14-,17+/m1/s1
Synonyms:
  • (5R)-3-[4-[1-[(2S)-2,3-Dihydroxy-1-oxopropyl]-1,2,3,6-tetrahydro-4-pyridinyl]-3,5-difluorophenyl]-5-[(3-isoxazolyloxy)methyl]-2-oxazolidinone
  • (5R)-3-(4-{1-[(2S)-2,3-dihydroxypropanoyl]-1,2,3,6-tetrahydropyridin-4-yl}-3,5-difluorophenyl)-5-[(1,2-oxazol-3-yloxy)methyl]-1,3-oxazolidin-2-one
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