CAS 252337-60-3

Uridine,5-[3-[(6-aminohexyl)amino]-3-oxo-1-propenyl]-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-

Description:

Uridine, 5-[3-[(6-aminohexyl)amino]-3-oxo-1-propenyl]-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy- is a complex organic compound that belongs to the class of nucleosides. It features a uridine backbone, which is a nucleoside composed of a ribose sugar and a uracil base, modified with various functional groups that enhance its biological activity. The presence of an aminohexyl chain suggests potential for interaction with biological systems, possibly enhancing cellular uptake or targeting specific receptors. The compound also contains a propenyl group, which may contribute to its reactivity or ability to form covalent bonds with other molecules. The bis(4-methoxyphenyl)phenylmethyl moiety indicates a significant degree of aromatic character, which could influence its solubility and interaction with other organic compounds. Overall, this substance may exhibit unique pharmacological properties, making it of interest in medicinal chemistry and drug development, particularly in the context of nucleoside analogs or therapeutic agents targeting nucleic acid processes.

Formula: C₃₉H₄₆N₄O₈

InChI: InChI=1S/C39H46N4O8/c1-48-31-17-13-29(14-18-31)39(28-10-6-5-7-11-28,30-15-19-32(49-2)20-16-30)50-26-34-33(44)24-36(51-34)43-25-27(37(46)42-38(43)47)12-21-35(45)41-23-9-4-3-8-22-40/h5-7,10-21,25,33-34,36,44H,3-4,8-9,22-24,26,40H2,1-2H3,(H,41,45)(H,42,46,47)/t33-,34+,36+/m0/s1

InChI key: InChIKey=LZRVIYIHUBJELH-GABYNLOESA-N

SMILES: C(OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(C=CC(NCCCCCCN)=O)C(=O)NC2=O)(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5

Synonyms:

• 5-[3-[(6-Aminohexyl)amino]-3-oxo-1-propen-1-yl]-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine
• Uridine, 5-[3-[(6-aminohexyl)amino]-3-oxo-1-propen-1-yl]-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-
• Uridine, 5-[3-[(6-aminohexyl)amino]-3-oxo-1-propenyl]-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-
• 5-[N-(6-AMINOHEXYL)-3-(E)-ACRYLAMIDO]-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYURIDINE
• 5-[N-(6-AMINOHEXYL)-3-(E)-ACRYLAMIDO]-5'-O-(DMT)-2'-DEOXYURIDINE
• 5-[N-(6-Aminoethyl)-3-E-acrylamido]-2'-deoxy-5'-O-DMT-uridine
• 5’-DMT-5-aha-dC
• 5'-DMT-5-[N-(6-Aminohexyl)-3-E-acrylamido]-2'-deoxyuridine
• 5'-DMT-5-AHA-DU
• 5-[N-(6-Aminohexyl)-3-E-acrylamido]-2'-deoxy-5'-O-DMT-uridine
• 5'-DMT-5-aha-2'-deoxyuridine

5-[3-[(6-Aminohexyl)amino]-3-oxo-1-propen-1-yl]-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-Uridine

CAS: 252337-60-3

5-[3-[(6-Aminohexyl)amino]-3-oxo-1-propen-1-yl]-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-Uridine

Purity: 97%

Molecular weight: 698.82g/mol

Ref: 54-OR1058502

5-[N-(6-Aminohexyl)-3-E-acrylamido]-2''-deoxy-5''-O-DMT-uridine

CAS: 252337-60-3

Ref: 7W-GN6847

5-[N-(6-Aminohexyl)-3-E-acrylamido]-2'-deoxy-5'-O-DMT-uridine

CAS: 252337-60-3

5-[N-(6-Aminohexyl)-3-E-acrylamido]-2'-deoxy-5'-O-DMT-uridine is a novel, activator ribonucleoside derived from the modified nucleosides 5-[N-(6-aminohexyl)-3-E-acrylamido]-2'-deoxyadenosine and 2'-deoxyuridine. It has been shown to be an effective anticancer, antiviral and antiparasitic agent. 5-[N-(6-Aminohexyl)-3-E-acrylamido]-2'-deoxy-5'-O-DMT-uridine has exhibited anticancer activity against human leukemia cells in culture, inhibiting DNA synthesis by blocking the enzyme DNA polymerase. This novel compound also blocks viral replication by inhibiting the synthesis of RNA by an enzyme called RNA polymerase II.

Formula: C₃₉H₄₆N₄O₈

Purity: Min. 95%

Molecular weight: 698.82 g/mol

Ref: 3D-NA08232