CAS 252870-53-4

Ispronicline

Description:

Ispronicline is a chemical compound that functions primarily as a selective alpha-7 nicotinic acetylcholine receptor agonist. It has garnered attention for its potential therapeutic applications, particularly in the treatment of cognitive deficits associated with conditions such as Alzheimer's disease and schizophrenia. The compound is characterized by its ability to enhance cognitive function and improve memory by modulating neurotransmitter release in the brain. Ispronicline exhibits a favorable pharmacokinetic profile, which includes good oral bioavailability and a manageable half-life, making it suitable for clinical use. Its chemical structure features specific functional groups that contribute to its receptor selectivity and activity. Additionally, Ispronicline has undergone various preclinical and clinical studies to assess its efficacy and safety, demonstrating a promising profile in enhancing cognitive performance without significant adverse effects. As research continues, Ispronicline may offer new avenues for treating neurodegenerative and psychiatric disorders, highlighting the importance of nicotinic receptors in cognitive health.

Formula: C₁₄H₂₂N₂O

InChI: InChI=1S/C14H22N2O/c1-11(2)17-14-8-13(9-16-10-14)7-5-6-12(3)15-4/h5,7-12,15H,6H2,1-4H3/b7-5+/t12-/m0/s1

InChI key: InChIKey=RPCVIAXDAUMJJP-PZBABLGHSA-N

SMILES: C(=C/C[C@@H](NC)C)\C=1C=C(OC(C)C)C=NC1

Synonyms:

• (2S,4E)-N-Methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine
• (2S,4E)-N-Methyl-5-[5-(1-methylethoxy)-3-pyridinyl]-4-penten-2-amine
• TC 01734
• 4-Penten-2-amine, N-methyl-5-[5-(1-methylethoxy)-3-pyridinyl]-, (2S,4E)-
• Ispronicline

Ispronicline

CAS: 252870-53-4

Ispronicline

Purity: ≥95%

Molecular weight: 234.34g/mol

Ref: 54-BUP13131

Ispronicline

CAS: 252870-53-4

Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive

Formula: C₁₄H₂₂N₂O

Purity: 97.70% - 99.16%

Color and Shape: Solid

Molecular weight: 234.34

Ref: TM-T27636

Ispronicline

CAS: 252870-53-4

Ispronicline is a nicotinic acetylcholine receptor (nAChR) agonist that binds to the α7-nAChR subtype. It has been shown to reduce the symptoms of cancer, such as depression and anxiety, by increasing the release of neurotrophic factors. Ispronicline may also be used in combination with other drugs, such as dimethyl fumarate or acetylcholinesterase inhibitors, for the treatment of neurodegenerative disorders. Ispronicline binds to nAChRs on central nervous system neurons and peripheral nerves. This binding enhances neurotransmitter release from nerve endings, which stimulates nicotinic receptors on adjacent cells, leading to an increased release of dopamine. Ispronicline has a terminal half-life of about 2 hours and is metabolized by CYP3A4 enzymes in the liver. Metformin hydrochloride can inhibit CYP3A4 enzyme activity and increase blood levels of is

Formula: C₁₄H₂₂N₂O

Purity: Min. 95%

Molecular weight: 234.34 g/mol

Ref: 3D-CKA87053