CAS 252920-94-8

Solabegron

Description:

Solabegron is a selective beta-3 adrenergic receptor agonist, primarily investigated for its potential therapeutic applications in treating overactive bladder and other conditions related to urinary incontinence. As a chemical entity, it exhibits a unique structure that allows it to selectively activate beta-3 adrenergic receptors, which play a crucial role in bladder relaxation and increased capacity. Solabegron is characterized by its moderate lipophilicity, which influences its absorption and distribution in biological systems. The compound is typically administered orally and has been studied for its pharmacokinetic properties, including metabolism and excretion pathways. Its safety profile and efficacy have been evaluated in clinical trials, highlighting its potential benefits over traditional treatments for urinary disorders. However, as with any pharmacological agent, the therapeutic use of Solabegron may be accompanied by side effects, which necessitate careful consideration in clinical settings. Overall, Solabegron represents a promising advancement in the management of bladder-related conditions, reflecting ongoing research in the field of urology and pharmacotherapy.

Formula: C₂₃H₂₃ClN₂O₃

InChI: InChI=1S/C23H23ClN2O3/c24-20-8-2-6-18(13-20)22(27)15-25-10-11-26-21-9-3-5-17(14-21)16-4-1-7-19(12-16)23(28)29/h1-9,12-14,22,25-27H,10-11,15H2,(H,28,29)/t22-/m0/s1

InChI key: InChIKey=LLDXOPKUNJTIRF-QFIPXVFZSA-N

SMILES: C(O)(=O)C=1C=C(C=CC1)C2=CC(NCCNC[C@H](O)C3=CC(Cl)=CC=C3)=CC=C2

Synonyms:

• (-)-(R)-3′-[[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]biphenyl-3-carboxylic acid
• 3′-[[2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino][1,1′-biphenyl]-3-carboxylic acid
• Gw 427353
• Solabegron
• [1,1′-Biphenyl]-3-carboxylic acid, 3′-[[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-

[1,1'-Biphenyl]-3-carboxylicacid,3'-[[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]aMino]ethyl]aMino]-

CAS: 252920-94-8

Formula: C₂₃H₂₃ClN₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 410.8933

Ref: IN-DA00BHU6

Solabegron

CAS: 252920-94-8

Solabegron (GW 427353) is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR

Formula: C₂₃H₂₃ClN₂O₃

Purity: 97.89%

Color and Shape: Solid

Molecular weight: 410.89

Ref: TM-T12970

Solabegron

CAS: 252920-94-8

Solabegron

Purity: ≥95%

Molecular weight: 410.89g/mol

Ref: 54-BUP08893

Solabegron-d8 HCl

CAS: 252920-94-8

Formula: C₂₃H₁₅ClN₂O₃D₈·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 418.95 36.46

Ref: 4Z-S-090002

Solabegron

Controlled Product

CAS: 252920-94-8

Formula: C₂₃H₂₃ClN₂O₃

Color and Shape: Neat

Molecular weight: 410.893

Ref: TR-S676505

Solabegron-13C6

Controlled Product

CAS: 252920-94-8

Formula: C₆C₁₇H₂₃ClN₂O₃

Color and Shape: Neat

Molecular weight: 416.849

Ref: TR-S676506

Solabegron

CAS: 252920-94-8

Solabegron is a drug that has clinical relevance for the treatment of bladder disorders. It is an agonist of the beta-3 adrenergic receptor, with no affinity for beta-1 or beta-2 receptors. In animal models, solabegron has been shown to increase detrusor muscle contractility and reduce urinary symptoms. Solabegron also acts as an inhibitor of DPP-IV, which is involved in the breakdown of glucagon-like peptide (GLP). The drug reduces body mass index and improves metabolic disorders in animals by stimulating GLP secretion. Solabegron is metabolized by CYP3A4 and has hydrogen bonding interactions with drugs such as erythromycin, clarithromycin, and telithromycin.

Formula: C₂₃H₂₃ClN₂O₃

Purity: Min. 95%

Molecular weight: 410.89 g/mol

Ref: 3D-CKA92094