CAS 252964-65-1

trans-Itraconazole

Description:

Trans-Itraconazole is a triazole antifungal agent primarily used in the treatment of various fungal infections. It is characterized by its ability to inhibit the synthesis of ergosterol, a vital component of fungal cell membranes, thereby disrupting their integrity and function. This compound exhibits a broad spectrum of antifungal activity against various pathogens, including dermatophytes and yeasts. Trans-Itraconazole is known for its favorable pharmacokinetic properties, including good oral bioavailability and a long half-life, which allows for once-daily dosing in clinical settings. The substance is typically administered in its oral form and is metabolized in the liver, with its efficacy influenced by factors such as pH and the presence of food. Additionally, trans-Itraconazole has been studied for its potential anti-inflammatory and immunomodulatory effects, expanding its therapeutic applications beyond antifungal treatment. Safety profiles indicate that it may cause side effects, including liver enzyme elevation and gastrointestinal disturbances, necessitating monitoring during therapy. Overall, trans-Itraconazole represents a significant advancement in antifungal pharmacotherapy.

Formula: C₃₅H₃₈Cl₂N₈O₄

Synonyms:

• Itraconazole EP Impurity E (trans-Itraconazole)
• 4-[4-[4-[4-[[trans-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(1RS)-1-methylpropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
• Itraconazole Impurity 5(Itraconazole EP Impurity E)
• 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2R,4R)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-, rel-
• 4-(4-(4-(4-(((2S,4S)-2-((1H-1,2,4-triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-(sec-butyl)-1H-1,2,4-triazol-5(4H)-one
• Itraconazole iMpurity E
• trans-Itraconazole

Itraconazole EP Impurity E

CAS: 252964-65-1

Formula: C₃₅H₃₈Cl₂N₈O₄

Color and Shape: White To Off-White Solid

Molecular weight: 705.64

Ref: 4Z-I-0322

Itraconazole EP Impurity E

CAS: 252964-65-1

Formula: C₃₅H₃₈Cl₂N₈O₄

Molecular weight: 705.64

Ref: ST-EA-CP-I3005

trans-Itraconazole

Controlled Product

CAS: 252964-65-1

Impurity Itraconazole EP Impurity E
Applications trans-Itraconazole (Itraconazole EP Impurity E) is a geometrical isomer of Itraconazole (I937500). It is a COVID19-related research product.
References Ahn, C., et al.: J. Korean Chem. Soc., 43, 676 (1999),

Formula: C₃₅H₃₈Cl₂N₈O₄

Color and Shape: Neat

Molecular weight: 705.63

Ref: TR-I937505

trans-Itraconazole

CAS: 252964-65-1

Itraconazole is an antimycotic agent that inhibits ergosterol synthesis by binding to the cytochrome P450 enzyme. It also inhibits the synthesis of other sterols, such as cholesterol and lanosterol. Itraconazole has been shown to be effective against infections caused by fungi and yeast, including candida, cryptococcus, histoplasma, blastomyces, and aspergillus. A long-term treatment with itraconazole can disrupt the normal balance of the microflora in the intestines, leading to gastrointestinal disturbances. Itraconazole is available as a tablet for oral administration.

Formula: C₃₅H₃₈Cl₂N₈O₄

Purity: Min. 95%

Molecular weight: 705.63 g/mol

Ref: 3D-FI24742