CAS 252964-68-4

2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one

Description:

2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one, with CAS number 252964-68-4, is a synthetic organic compound characterized by its complex molecular structure, which includes a triazole ring, piperazine moiety, and methoxyphenyl group. This compound exhibits properties typical of triazole derivatives, such as potential antifungal and antimicrobial activities, due to the presence of the triazole functional group, which is known for its ability to interact with biological targets. The piperazine ring contributes to its pharmacological profile, often enhancing solubility and bioavailability. Additionally, the methoxy group may influence the compound's lipophilicity and overall biological activity. The presence of the isopropyl group further modifies its steric and electronic properties, potentially affecting its interaction with biological systems. Overall, this compound's unique structure suggests it may have applications in medicinal chemistry, particularly in the development of therapeutic agents. However, specific biological activities and safety profiles would require further investigation through experimental studies.

Formula: C₂₃H₂₉N₅O₂

InChI: InChI=1S/C23H29N5O2/c1-4-18(2)28-23(29)27(17-24-28)21-7-5-19(6-8-21)25-13-15-26(16-14-25)20-9-11-22(30-3)12-10-20/h5-12,17-18H,4,13-16H2,1-3H3

InChI key: InChIKey=IVIVGYTUQVJVPF-UHFFFAOYSA-N

SMILES: O=C1N(C=NN1C(CC)C)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(OC)C=C4

Synonyms:

• 2-Butan-2-yl-4-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-one
• 3H-1,2,4-Triazol-3-one, 2,4-dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-
• 4-{4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl}-2-(1-methylpropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
• 2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one

4-Methoxy Itraconazole Derivative (2-sec-Butyl-4-{4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl}-2H-1,2,4-triazol-3(4H)-one)

CAS: 252964-68-4

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Formula: C₂₃H₂₉N₅O₂

Color and Shape: Off-White Powder

Molecular weight: 407.23213

Ref: 45-1A06380

2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3h-1,2,4-triazol-3-one

CAS: 252964-68-4

Formula: C₂₃H₂₉N₅O₂

Color and Shape: Solid

Molecular weight: 407.5087

Ref: IN-DA00BBXR

Itraconazole EP Impurity A

CAS: 252964-68-4

Formula: C₂₃H₂₉N₅O₂

Color and Shape: Pale Pink Solid

Molecular weight: 407.52

Ref: 4Z-I-0319

4-[4-[4-(4-Methoxyphenyl)piperazin-1-yl]phenyl]-2-[(1RS)-1-methylpropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Controlled Product

CAS: 252964-68-4

Formula: C₂₃H₂₉N₅O₂

Color and Shape: Neat

Molecular weight: 407.51

Ref: 86-MM0258.02

Itraconazole EP Impurity A

CAS: 252964-68-4

Formula: C₂₃H₂₉N₅O₂

Molecular weight: 407.52

Ref: ST-EA-CP-I3001

2-(2-Butyl)-4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one

CAS: 252964-68-4

2-(2-Butyl)-4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one (ITZ) is an antifungal drug that inhibits the synthesis of ergosterol. It is used in the treatment of systemic fungal infections such as candidiasis and cryptococcosis. ITZ is a metabolite of itraconazole and fluconazole. The presence of impurities in ITZ can be detected by liquid chromatography with a diode array detector or a fluorescence detector. An antiinfective drug product should be bioequivalent to the reference product and have comparable levels of impurities. Chromatograms are used to identify peaks on a graph and measure their height (area under the curve) to determine how much of each substance is present in the sample.

Formula: C₂₃H₂₉N₅O₂

Purity: Min. 95%

Color and Shape: White To Yellow Solid

Molecular weight: 407.51 g/mol

Ref: 3D-FB19470

2-(Sec-butyl)-4-(4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

CAS: 252964-68-4

Purity: 97%

Molecular weight: 407.5180054

Ref: 10-F727520

2-(2-Butyl)-4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one

Controlled Product

CAS: 252964-68-4

Impurity Itraconazole EP Impurity A
Applications 2-(2-Butyl)-4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one (Itraconazole EP Impurity A) is an intermediate of Itraconazole.

Formula: C₂₃H₂₉N₅O₂

Color and Shape: Beige

Molecular weight: 407.51

Ref: TR-B693320