CAS 253128-41-5

Eribulin

Description:

Eribulin, with the CAS number 253128-41-5, is a synthetic analog of the natural product halichondrin B, derived from marine sponges. It is classified as a microtubule dynamics inhibitor, specifically targeting the mitotic spindle during cell division. Eribulin's mechanism of action involves binding to tubulin, preventing its polymerization into microtubules, which disrupts the normal function of the mitotic spindle and ultimately leads to apoptosis in rapidly dividing cancer cells. This compound is primarily used in the treatment of metastatic breast cancer and liposarcoma, particularly in patients who have previously undergone multiple therapies. Eribulin is administered intravenously and has a unique pharmacokinetic profile, characterized by a relatively long half-life and a low volume of distribution. Its side effects may include fatigue, neutropenia, and peripheral neuropathy, which are common in chemotherapeutic agents. Overall, Eribulin represents a significant advancement in cancer therapy, offering a novel mechanism of action compared to traditional chemotherapeutics.

Formula: C₄₀H₅₉NO₁₁

InChI: InChI=1S/C40H59NO11/c1-19-11-24-5-7-28-20(2)12-26(45-28)9-10-40-17-33-36(51-40)37-38(50-33)39(52-40)35-29(49-37)8-6-25(47-35)13-22(42)14-27-31(16-30(46-24)21(19)3)48-32(34(27)44-4)15-23(43)18-41/h19,23-39,43H,2-3,5-18,41H2,1,4H3/t19-,23+,24+,25-,26+,27+,28+,29+,30-,31+,32-,33-,34-,35+,36+,37+,38-,39+,40+/m1/s1

InChI key: InChIKey=UFNVPOGXISZXJD-JBQZKEIOSA-N

SMILES: C=C1C[C@@]2(CC[C@@]34O[C@@]5([C@]6([C@]([C@@](O3)([C@@](C4)(O6)[H])[H])(O[C@@]7([C@@]5(O[C@](CC7)(CC(=O)C[C@]8([C@@](O[C@H](C[C@@H](CN)O)[C@@H]8OC)(C[C@]9(O[C@@](CC[C@@]1(O2)[H])(C[C@@H](C)C9=C)[H])[H])[H])[H])[H])[H])[H])[H])[H])[H])[H]

Synonyms:

• (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,35R,36S)-20-[3-Amino-2(S)-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1(3,32).1(3,33).1(6,9).1(12,16).0(18,22).0(29,36).0(31,35)]hentetraconta
• (2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-2-[(2S)-3-Amino-2-hydroxypropyl]hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-11,15:18,21:24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2′,3′:5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one
• (2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-2-[3-Amino-2(S)-hydroxypropyl]-3-methoxy-26-methyl-20,27-bis(methylene)-11,15:18,21:24,28-triepoxy-7,9-ethano-12,15-methanoperhydro-9H,15H-furo[3,2-i]furo[2',3':5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5-one
• 11,15:18,21:24,28-Triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2′,3′:5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one, 2-[(2S)-3-amino-2-hydroxypropyl]hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-, (2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-
• B-1939
• E-7389
• Er-086526
• Nsc-707389

Eribulin

CAS: 253128-41-5

Eribulin

Formula: C₄₀H₅₉NO₁₁

Purity: ≥98%

Color and Shape: Solid

Molecular weight: 729.9

Ref: 54-BUP01573

Eribulin

CAS: 253128-41-5

Formula: C₄₀H₅₉NO₁₁

Purity: 98%

Color and Shape: Solid

Molecular weight: 729.8966

Ref: IN-DA00BF33

Eribulin

CAS: 253128-41-5

(2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-2-[(2S)-3-Amino-2-hydroxypropyl]hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-11,15:18,21:24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2',3':5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one

Formula: C₄₀H₅₉NO₁₁

Purity: 99%

Molecular weight: 729.9

Ref: IN-DG630592

Eribulin

CAS: 253128-41-5

Eribulin binds microtubules, halts cancer cell growth, treating metastatic breast cancer.

Formula: C₄₀H₅₉NO₁₁

Purity: 99.59%

Color and Shape: Solid

Molecular weight: 729.8966

Ref: TM-T13688