CAS 25316-40-9
:Doxorubicin hydrochloride
Description:
Doxorubicin hydrochloride is an anthracycline antibiotic commonly used in cancer chemotherapy. It is characterized by its bright red color and is known for its potent antitumor activity. The compound works by intercalating DNA, thereby inhibiting the synthesis of nucleic acids and disrupting the replication of cancer cells. Doxorubicin is soluble in water and exhibits a pH-dependent solubility profile, which is important for its formulation and administration. Its mechanism of action also involves the generation of free radicals, contributing to its cytotoxic effects. However, the use of doxorubicin is associated with several side effects, including cardiotoxicity, which limits its cumulative dose. It is typically administered intravenously and is often used in combination with other chemotherapeutic agents to enhance efficacy against various malignancies, including breast cancer, leukemia, and lymphomas. Due to its significant therapeutic benefits and potential risks, careful monitoring and management are essential during treatment.
Formula:C27H29NO11·ClH
InChI:InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
InChI key:InChIKey=MWWSFMDVAYGXBV-RUELKSSGSA-N
SMILES:OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5.Cl
Synonyms:- (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride (1:1)
- (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride (1:1)
- (8S-Cis)-10-((3-Amino-2,3,6-Trideoxy-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxynaphthacene-5,12-Dione Hydrochloride
- (8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid
- (8S-cis)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
- (8S-cis)-10-[(3-amino-2,3,6-tridesoxi-α-L-lyxo-hexopiranosil)oxi]-7,8,9,10-tetrahidro-6,8,11-trihidroxi-8-(hidroxiacetil)-1-metoxinaftaceno-5,12-diona, clorhidrato
- (8S-cis)-10-[(3-amino-2,3,6-tridesoxy-α-L-lyxo-hexopyrannosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphtacene-5,12-dione, chlorhydrate
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
- ADM hydrochloride
- ADR
- Adriablastina CS
- Adriacin
- Adriamycin
- Adriamycin, hydrochloride
- Adriblastin
- Adriblastina
- Adriblastina RD
- Adrosal
- Ameisu hydrochloride
- Caelyx pegylated liposomal
- DOX HCl
- Doxolipad
- Doxorubicin, HCl
- Doxorubicin-LANS
- Doxorubicin-TEVA
- Doxourbicin HCl
- Fi 106
- Fi 6804
- Hydroxydaunorubicin hydrochloride
- Lipo-Dox
- Lipodox
- Myocet liposomal
- See more synonyms
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Found 27 products.
Doxorubicin Hydrochloride
CAS:Formula:C27H29NO11·HClPurity:>95.0%(HPLC)Color and Shape:Light yellow to Brown powder to crystalMolecular weight:579.98Doxorubicin hydrochloride
CAS:<p>Doxorubicin hydrochloride, 25316-40-9, also known as Lipodox, is an anthracycline antibiotic with anti-cancer properties. Learn more at Thermo Fisher Scientific.</p>Formula:C27H30ClNO11Color and Shape:Crystalline powder or granular, Red to orangeMolecular weight:579.98DOXORUBICIN HYDROCHLORIDE CRS
CAS:<p>DOXORUBICIN HYDROCHLORIDE CRS</p>Formula:C27H29NO11Color and Shape:Crystalline Powder. Orange. Red. Powder.Molecular weight:543.5193Doxorubicin hydrochloride
CAS:Doxorubicin hydrochlorideFormula:C27H29NO11HClPurity:99.0%Color and Shape:Orange To Dark RedMolecular weight:579.15074DOXORUBICIN HYDROCHLORIDE RS
CAS:<p>DOXORUBICIN HYDROCHLORIDE RS</p>Formula:C27H29NO11Molecular weight:543.5193Doxorubicin Hydrochloride
CAS:<p>Antibiotics nesoi</p>Formula:C27H29NO11·ClHColor and Shape:Red Orange Crystalline Powder Amorphous PowderMolecular weight:579.15074(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
CAS:Formula:C27H30ClNO11Purity:98%Color and Shape:SolidMolecular weight:579.9802Doxorubicin hydrochloride
CAS:<p>Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).</p>Formula:C27H29NO11·HClPurity:98% - 99.52%Color and Shape:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Molecular weight:579.99Doxorubicin hydrochloride
CAS:<p>Doxorubicin hydrochloride</p>Purity:≥98%Molecular weight:579.99g/molDoxorubicin hydrochloride
CAS:<p>Doxorubicin hydrochloride</p>Formula:C27H29NO11·ClHPurity:99%Color and Shape: orange red crystalline powderMolecular weight:579.98019g/molDoxorubicin hydrochloride, USP grade
CAS:Formula:C27H29NO11·HClPurity:≥ 98.0% (anhydrous, solvent-free)Color and Shape:Orange-red to red crystalline powderMolecular weight:579.99Doxorubicin HCl (Daunorubicin EP Impurity D HCl, Epirubicin EP Impurity C HCl)
CAS:Formula:C27H29NO11·HClColor and Shape:Red SolidMolecular weight:543.53 36.46Doxorubicin hydrochloride, 98%
CAS:Formula:C27H29NO11·HClPurity:(HPLC) 98.0 - 102.0 % (anhydrous, solvent free)Color and Shape:Orange-red to red crystalline powderMolecular weight:579.99Doxorubicin Hydrochloride
CAS:Controlled ProductFormula:C27H29NO11·ClHColor and Shape:NeatMolecular weight:579.98Doxorubicin-13C-d3 HCl (Daunorubicin EP Impurity D-13C-d3 HCl, Epirubicin EP Impurity C-13C-d3 HCl)
CAS:Formula:C13C22H26D3NO11·HClMolecular weight:547.56 36.45Doxorubicin Hydrochloride
CAS:<p>Stability Hygroscopic, Light Sensitive<br>Applications Doxorubicin Hydrochloride is an antineoplastic agent.<br>References Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969); Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984);<br></p>Formula:C27H29NO11·ClHColor and Shape:NeatMolecular weight:579.98Doxorubicin hydrochloride
CAS:<p>Doxorubicin is a cytotoxic drug that belongs to the class of anthracyclines. It is used as an anticancer agent and in the treatment of various types of cancer. Doxorubicin has been shown to inhibit glucose uptake by cells, which may be due to its ability to form disulfide bonds with proteins. Doxorubicin also binds to iron-sulfur clusters, causing cell lysis, which may lead to tumor necrosis. In vitro assays have shown that doxorubicin inhibits drug transporter function, leading to reduced cellular uptake of drugs.</p>Formula:C27H29NO11•HClPurity:Min. 95%Molecular weight:579.98 g/molDoxorubicin hydrochloride - Bio-X ™
CAS:<p>Doxorubicin hydrochloride is an inhibitor of topoisomerase II with anti-neoplastic activity and belongs to the class of anthracyclines. It is cytotoxic, and interferes with the topoisomerase II-mediated repair of DNA causing accumulation of mutations. Doxorubicin also leads to the generation of reactive oxygen species (ROS), which further damages DNA as well as proteins and membranes. Doxorubicin is used as a chemotherapy treatment for various types of cancer, including breast cancer, lung cancer, ovarian cancer, and leukaemia. However, the compound presents with a risk of developing cardiomyopathy as well as drug resistance.</p>Formula:C27H29NO11•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:579.98 g/molDoxorubicin HCl
CAS:<p>Doxorubicin (DOX) is an antineoplastic chemotherapy drug used to treat breast, ovarian and pancreatic cancers. It is an antitumor antibiotic that inhibits DNA topoisomerase II. DOX interferes with the topoisomerase II-mediated repair of DNA causing accumulation of mutations. It also leads to the generation of reactive oxygen species (ROS), which further damage DNA as well as proteins and membranes. However, the compound presents with a risk of developing cardiomyopathy as well as drug resistance. Pegylated liposomal doxorubicin has also been developed to treat breast and ovarian cancers, myeloma, and HIV-related Kaposi’s sarcoma.</p>Formula:C27H29NO11·HClPurity:Min. 98 Area-%Color and Shape:Red PowderMolecular weight:579.98 g/molDoxorubicin hydrochloride
CAS:Formula:C27H30ClNO11Purity:95.0%Color and Shape:Solid, Crystalline Powder or Granules or PowderMolecular weight:579.98Doxorubicin hydrochloride, 10 mg/ml aqueous solution
CAS:<p>Doxorubicin hydrochloride, 10 mg/ml aqueous solution, is a chemotherapeutic agent, which is an anthracycline antibiotic derived from the bacterium *Streptomyces peucetius var. caesius*. Its mode of action involves the intercalation into DNA, disrupting the replication and transcription processes crucial for cancer cell proliferation. Additionally, it generates free radicals that cause further damage to cellular structures and inhibit topoisomerase II, thereby preventing the unwinding of DNA necessary for replication.</p>Formula:C27H29NO11•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:579.98 g/molDes-[(4-Amino-2,3,6-trideoxy-hexapyranosyl)oxy)-1-methyl] 2-Carboxylate Doxorubicin
CAS:Controlled ProductFormula:C20H12O7Color and Shape:NeatMolecular weight:364.305
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