CAS 25316-40-9
:Doxorubicin hydrochloride
Description:
Doxorubicin hydrochloride is an anthracycline antibiotic commonly used in cancer chemotherapy. It is characterized by its bright red color and is known for its potent antitumor activity. The compound works by intercalating DNA, thereby inhibiting the synthesis of nucleic acids and disrupting the replication of cancer cells. Doxorubicin is soluble in water and exhibits a pH-dependent solubility profile, which is important for its formulation and administration. Its mechanism of action also involves the generation of free radicals, contributing to its cytotoxic effects. However, the use of doxorubicin is associated with several side effects, including cardiotoxicity, which limits its cumulative dose. It is typically administered intravenously and is often used in combination with other chemotherapeutic agents to enhance efficacy against various malignancies, including breast cancer, leukemia, and lymphomas. Due to its significant therapeutic benefits and potential risks, careful monitoring and management are essential during treatment.
Formula:C27H29NO11·ClH
InChI:InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
InChI key:InChIKey=MWWSFMDVAYGXBV-RUELKSSGSA-N
SMILES:OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5.Cl
Synonyms:- (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride (1:1)
- (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride (1:1)
- (8S-Cis)-10-((3-Amino-2,3,6-Trideoxy-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxynaphthacene-5,12-Dione Hydrochloride
- (8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid
- (8S-cis)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
- (8S-cis)-10-[(3-amino-2,3,6-tridesoxi-α-L-lyxo-hexopiranosil)oxi]-7,8,9,10-tetrahidro-6,8,11-trihidroxi-8-(hidroxiacetil)-1-metoxinaftaceno-5,12-diona, clorhidrato
- (8S-cis)-10-[(3-amino-2,3,6-tridesoxy-α-L-lyxo-hexopyrannosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphtacene-5,12-dione, chlorhydrate
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
- ADM hydrochloride
- ADR
- Adriablastina CS
- Adriacin
- Adriamycin
- Adriamycin, hydrochloride
- Adriblastin
- Adriblastina
- Adriblastina RD
- Adrosal
- Ameisu hydrochloride
- Caelyx pegylated liposomal
- DOX HCl
- Doxolipad
- Doxorubicin, HCl
- Doxorubicin-LANS
- Doxorubicin-TEVA
- Doxourbicin HCl
- Fi 106
- Fi 6804
- Hydroxydaunorubicin hydrochloride
- Lipo-Dox
- Lipodox
- Myocet liposomal
- See more synonyms
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Doxorubicin Hydrochloride
CAS:Formula:C27H29NO11·HClPurity:>95.0%(HPLC)Color and Shape:Light yellow to Brown powder to crystalMolecular weight:579.98Doxorubicin hydrochloride
CAS:Doxorubicin hydrochloride, 25316-40-9, also known as Lipodox, is an anthracycline antibiotic with anti-cancer properties. Learn more at Thermo Fisher Scientific.Formula:C27H30ClNO11Color and Shape:Crystalline powder or granular, Red to orangeMolecular weight:579.98DOXORUBICIN HYDROCHLORIDE RS
CAS:DOXORUBICIN HYDROCHLORIDE RSFormula:C27H29NO11Molecular weight:543.5193Doxorubicin hydrochloride
CAS:Doxorubicin hydrochlorideFormula:C27H29NO11HClPurity:99.0%Color and Shape:Orange To Dark RedMolecular weight:579.15074DOXORUBICIN HYDROCHLORIDE CRS
CAS:DOXORUBICIN HYDROCHLORIDE CRSFormula:C27H29NO11Color and Shape:Crystalline Powder. Orange. Red. Powder.Molecular weight:543.5193Doxorubicin Hydrochloride
CAS:Antibiotics nesoiFormula:C27H29NO11·ClHColor and Shape:Red Orange Crystalline Powder Amorphous PowderMolecular weight:579.15074Doxorubicin hydrochloride
CAS:Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).Formula:C27H29NO11·HClPurity:98% - 99.99%Color and Shape:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Molecular weight:579.99Doxorubicin hydrochloride
CAS:Doxorubicin hydrochlorideFormula:C27H29NO11·ClHPurity:99%Color and Shape:Orange-red SolidMolecular weight:579.98019Doxorubicin-13C-d3 HCl (Daunorubicin EP Impurity D-13C-d3 HCl, Epirubicin EP Impurity C-13C-d3 HCl)
CAS:Formula:C13C22H26D3NO11·HClMolecular weight:547.56 36.45Doxorubicin HCl (Daunorubicin EP Impurity D HCl, Epirubicin EP Impurity C HCl)
CAS:Formula:C27H29NO11·HClColor and Shape:Red SolidMolecular weight:543.53 36.46Doxorubicin hydrochloride, 98%
CAS:Formula:C27H29NO11·HClPurity:(HPLC) 98.0 - 102.0 % (anhydrous, solvent free)Color and Shape:Orange-red to red crystalline powderMolecular weight:579.99Doxorubicin hydrochloride, USP grade
CAS:Formula:C27H29NO11·HClPurity:≥ 98.0% (anhydrous, solvent-free)Color and Shape:Orange-red to red crystalline powderMolecular weight:579.99Doxorubicin hydrochloride
CAS:Doxorubicin hydrochlorideFormula:C27H29NO11·HClPurity:≥98%Color and Shape:SolidMolecular weight:579.99Doxorubicin Hydrochloride
CAS:Controlled ProductFormula:C27H29NO11·ClHColor and Shape:NeatMolecular weight:579.98Doxorubicin Hydrochloride
CAS:Stability Hygroscopic, Light Sensitive
Applications Doxorubicin Hydrochloride is an antineoplastic agent.
References Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969); Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984);Formula:C27H29NO11·ClHColor and Shape:NeatMolecular weight:579.98Doxorubicin hydrochloride
CAS:Doxorubicin is a cytotoxic drug that belongs to the class of anthracyclines. It is used as an anticancer agent and in the treatment of various types of cancer. Doxorubicin has been shown to inhibit glucose uptake by cells, which may be due to its ability to form disulfide bonds with proteins. Doxorubicin also binds to iron-sulfur clusters, causing cell lysis, which may lead to tumor necrosis. In vitro assays have shown that doxorubicin inhibits drug transporter function, leading to reduced cellular uptake of drugs.Formula:C27H29NO11•HClPurity:Min. 95%Molecular weight:579.98 g/molDoxorubicin hydrochloride - Bio-X ™
CAS:Doxorubicin hydrochloride is an inhibitor of topoisomerase II with anti-neoplastic activity and belongs to the class of anthracyclines. It is cytotoxic, and interferes with the topoisomerase II-mediated repair of DNA causing accumulation of mutations. Doxorubicin also leads to the generation of reactive oxygen species (ROS), which further damages DNA as well as proteins and membranes. Doxorubicin is used as a chemotherapy treatment for various types of cancer, including breast cancer, lung cancer, ovarian cancer, and leukaemia. However, the compound presents with a risk of developing cardiomyopathy as well as drug resistance.Formula:C27H29NO11•HClPurity:Min. 95%Color and Shape:PowderMolecular weight:579.98 g/mol
