CAS 253426-24-3

Propanamide, 2-amino-3-hydroxy-N-[2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]-, hydrochloride (1:1), (2S)-

Description:

Propanamide, 2-amino-3-hydroxy-N-[2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]-, hydrochloride (1:1), (2S)- is a complex organic compound characterized by its amide functional group, which is indicative of its potential as a pharmaceutical agent. The presence of multiple methoxy groups suggests enhanced lipophilicity, which may influence its bioavailability and interaction with biological membranes. The compound features a chiral center, denoted by the (2S) configuration, which can affect its pharmacodynamics and pharmacokinetics, making stereochemistry an important aspect of its activity. The hydrochloride salt form indicates improved solubility in aqueous environments, which is beneficial for formulation in drug development. Additionally, the presence of both amino and hydroxy groups contributes to its potential for hydrogen bonding, influencing its reactivity and interaction with other molecules. Overall, this compound's structural complexity and functional groups suggest it may have specific applications in medicinal chemistry, particularly in the development of therapeutic agents.

Formula: C₂₁H₂₆N₂O₆·ClH

InChI: InChI=1S/C21H26N2O6.ClH/c1-26-17-8-7-13(9-16(17)23-21(25)15(22)12-24)5-6-14-10-18(27-2)20(29-4)19(11-14)28-3;/h5-11,15,24H,12,22H2,1-4H3,(H,23,25);1H/b6-5-;/t15-;/m0./s1

InChI key: InChIKey=UQNRTPFLTRZEIM-MRWUDIQNSA-N

SMILES: O(C)C1=C(OC)C=C(/C=C\C2=CC(NC([C@H](CO)N)=O)=C(OC)C=C2)C=C1OC.Cl

Synonyms:

• Propanamide, 2-amino-3-hydroxy-N-[2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]-, hydrochloride (1:1), (2S)-
• AVE 8062
• Propanamide, 2-amino-3-hydroxy-N-[2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]-, monohydrochloride, (2S)-
• AC 7700
• AVE 8062A

Ombrabulin hydrochloride

CAS: 253426-24-3

Ombrabulin hydrochloride is a synthetic, selective CA-4 phosphate ester or derivative of Ombrabulin to disrupt the tubulin cytoskeleton of endothelial cells and

Formula: C₂₁H₂₇ClN₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 438.9

Ref: TM-T16386

Ombrabulin hydrochloride

CAS: 253426-24-3

Ombrabulin hydrochloride is a drug used in the treatment of cancer. It is a microtubule-stabilizing agent that interferes with tumor cell growth by inhibiting the production of vascular endothelial growth factor (VEGF). Ombrabulin hydrochloride has been shown to increase the microvessel density in tumors and reduce tumor perfusion, which may be due to its ability to inhibit VEGF production. Ombrabulin hydrochloride also inhibits angiogenesis by blocking the formation of new blood vessels from pre-existing ones, and can be used in combination with radiation therapy and platinum-based chemotherapy. The drug has been approved for use in patients with advanced solid tumors.

Formula: C₂₁H₂₇ClN₂O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 438.9 g/mol

Ref: 3D-DKA42624