CAS 253431-35-5

28-Epirapamycin

CAS: 253431-35-5

28-Epirapamycin, an impurity of Rapamycin, serves as a potent and specific mTOR inhibitor, exhibiting an IC50 value of 0.1 nM in HEK293 cells [1].

Formula: C₅₁H₇₉NO₁₃

Color and Shape: Solid

Molecular weight: 914.17

Ref: TM-T74084

28-epi-Rapamycin

CAS: 253431-35-5

Formula: C₅₁H₇₉NO₁₃

Molecular weight: 914.20

Ref: 4Z-R-185

28-Epirapamycin

Controlled Product

CAS: 253431-35-5

Applications 28-Epirapamycin is an epimer of Rapamycin (R124000), a triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants.
References Yang, W., et. al.: Org. Lett., 1, 2033 (1999); Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977); Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993); Kahan, B.D., et al.: Lancet, 356, 194 (2000); Holmes, D.R., et al.: Circulation, 109, 634 (2004)

Formula: C₅₁H₇₉NO₁₃

Purity: >90%

Color and Shape: Neat

Molecular weight: 914.17

Ref: TR-E588680

28-Epirapamycin

CAS: 253431-35-5

28-Epirapamycin is a semisynthetic derivative of the macrolide antibiotic rapamycin, which is derived from the bacterium *Streptomyces hygroscopicus*. This compound functions primarily as an mTOR (mechanistic target of rapamycin) inhibitor. The mTOR pathway is crucial for regulating cell growth, proliferation, and survival by integrating signals from nutrients, growth factors, and cellular energy status.

Formula: C₅₁H₇₉NO₁₃

Purity: Min. 95%

Molecular weight: 914.2 g/mol

Ref: 3D-DKA43135

28-Epi-Rapamycin

CAS: 253431-35-5

Formula: C₅₁H₇₉NO₁₃

Molecular weight: 914.19

Ref: ST-EA-CP-R26011