CAS 2537-48-6

Diethyl P-(cyanomethyl)phosphonate

Description:

Diethyl P-(cyanomethyl)phosphonate, with the CAS number 2537-48-6, is an organophosphorus compound characterized by its phosphonate structure, which includes a phosphorus atom bonded to an oxygen atom and two ethyl groups, along with a cyanomethyl group. This compound typically appears as a colorless to pale yellow liquid and is known for its use in organic synthesis and as an intermediate in the production of various chemicals. It exhibits moderate to high toxicity, primarily due to the presence of the phosphonate group, which can interfere with biological systems, particularly through inhibition of certain enzymes. The compound is soluble in organic solvents but has limited solubility in water. Its reactivity is influenced by the presence of the cyanomethyl group, which can participate in nucleophilic reactions. Safety precautions are essential when handling this substance, as it may pose health risks through inhalation, skin contact, or ingestion. Proper storage and disposal methods should be followed to mitigate environmental impact and ensure safety.

Formula: C₆H₁₂NO₃P

InChI: InChI=1S/C6H12NO3P/c1-3-9-11(8,6-5-7)10-4-2/h3-4,6H2,1-2H3

InChI key: InChIKey=KWMBADTWRIGGGG-UHFFFAOYSA-N

SMILES: P(CC#N)(OCC)(OCC)=O

Synonyms:

• (Cianometil)Fosfonato De Dietilo
• (Cyanomethyl)Phosphonate De Diethyle
• (Cyanomethyl)diethoxyphosphine oxide
• (Diethoxyphosphinyl)acetonitrile
• (Diethoxyphosphono)acetonitrile
• (Diethylphosphono)acetonitrile
• 2-(Diethylphosphonyl)acetonitrile
• 2-Diethoxyphosphorylacetonitrile
• Cyanomethanephosphonic acid, diethyl ester
• Cyanomethyl phosphonic acid diethyl ester
• Cyanomethylphosphonic acid diethyl ester~Diethyl phosphonoacetonitrile
• Diethyl (Cyanomethyl)Phosphonate
• Diethyl P-(cyanomethyl)phosphonate
• Diethyl cyanomethanephosphonate
• Diethyl cyanomethylphosphonoacetate
• Diethyl-(cyanomethyl)phosphonat
• Diethylphosphonoacetonitrile
• Nsc 407826
• O,O-Diethyl (cyanomethyl)phosphonate
• Phosphonic acid, (cyanomethyl)-, diethyl ester

Diethyl Cyanomethylphosphonate

CAS: 2537-48-6

Formula: C₆H₁₂NO₃P

Purity: >98.0%(GC)

Color and Shape: Colorless to Light yellow clear liquid

Molecular weight: 177.14

Ref: 3B-C1430

Diethyl cyanomethylphosphonate, 96%

CAS: 2537-48-6

Diethyl cyanomethyl phosphonate is used as an intermediate in Horner-Emmons reaction for the synthesis of substituted nitriles and their amide and heterocyclic derivatives. It is known as a modified Wittig reagent used in the preparation of alpha, beta-unsaturated nitriles from ketones or aldehydes

Formula: C₆H₁₂NO₃P

Purity: 96%

Color and Shape: Clear colorless to pale yellow, Liquid

Molecular weight: 177.14

Ref: 02-A10218

Diethyl cyanomethylphosphonate

CAS: 2537-48-6

Formula: C₆H₁₂NO₃P

Purity: 98%

Color and Shape: Liquid

Molecular weight: 177.1381

Ref: IN-DA0034Q8

Diethyl cyanomethylphosphonate

CAS: 2537-48-6

Formula: C₆H₁₂NO₃P

Purity: ≥ 98.0%

Color and Shape: Clear, colourless to faint yellow liquid

Molecular weight: 177.14

Ref: 7W-GK0911

Cyanomethylphosphonic acid diethyl ester

CAS: 2537-48-6

Formula: C₆H₁₂NO₃P

Purity: 98%

Color and Shape: Liquid, Light yellow clear liquid

Molecular weight: 177.14

Ref: 10-F003752

Diethyl Cyanomethylphosphonate

CAS: 2537-48-6

Formula: C₆H₁₂NO₃P

Molecular weight: 177.14

Ref: 4Z-P-5432

Diethyl (cyanomethyl)phosphonate

CAS: 2537-48-6

Diethyl (cyanomethyl)phosphonate

Formula: C₆H₁₂NO₃P

Purity: 98%

Color and Shape: colourless to light yellow liquid

Molecular weight: 177.13814g/mol

Ref: 54-OR6821

Diethylcyanomethylphosphonate

CAS: 2537-48-6

Diethylcyanomethylphosphonate is a hydrochloric acid salt of diethylcyanomethylphosphonic acid. It is used in the asymmetric synthesis of many organic molecules, including pharmaceuticals, and has been shown to have antiviral properties. Diethylcyanomethylphosphonate binds to the receptor on the surface of cells and inhibits their growth. This may be due to its ability to block the binding of sodium ions to cell receptors. The drug also prevents hydroxyl group metabolism and has been shown to be active against infectious diseases such as HIV and malaria.

Formula: C₆H₁₂NO₃P

Purity: Min. 95%

Color and Shape: Colorless Clear Liquid

Molecular weight: 177.14 g/mol

Ref: 3D-FD11127

Diethyl Cyanomethylphosphonate

Controlled Product

CAS: 2537-48-6

Applications A Wittig reagent.
References Laine, D., et al.: J. Med. Chem., 52, 5241 (2009), Nakao, A., et al.: Bioorg. Med. Chem. Lett., 19, 4607 (2009), Arakawa, Y., et al.: Chem. Pharm. Bull., 57, 167 (2009),

Formula: C₆H₁₂NO₃P

Color and Shape: Neat

Molecular weight: 177.14

Ref: TR-D444165