CAS 253863-19-3

(3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

Description:

The chemical substance with the name "(3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione" and CAS number "253863-19-3" is a complex organic compound characterized by its unique stereochemistry and functional groups. It features multiple hydroxyl (-OH) groups, which contribute to its potential solubility in polar solvents and may influence its biological activity. The presence of a methoxy (-OCH3) group suggests possible interactions in biological systems, enhancing its reactivity and potential as a pharmacophore. The compound's structure includes a benzoxacyclotetradecine framework, indicating a fused ring system that may impart rigidity and specificity in its interactions. The stereochemical descriptors (3S, 5Z, 8S, 9S, 11E) indicate specific spatial arrangements of atoms, which are crucial for determining the compound's reactivity and biological properties. Overall, this compound may exhibit interesting pharmacological properties, warranting further investigation in medicinal chemistry and related fields.

Formula: C₁₉H₂₂O₇

InChI: InChI=1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1

InChI key: InChIKey=NEQZWEXWOFPKOT-BYRRXHGESA-N

SMILES: OC1=C2C(=CC(OC)=C1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O

Synonyms:

• (3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
• (5Z)-7-Oxozeaenol
• 1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-
• 1H-2-Benzoxacyclotetradecin-1,7(8H)-dione,3,- 4,9,10-tetrahydro-8,9,16-trihydroxy-14- methoxy-3-methyl-,(3S,5E,8S,9S,11E)-
• C 292
• F 152
• Fr 148083
• L 783279
• f 152 A₁
• LL-Z 1640-2

LL Z1640-2

CAS: 253863-19-3

Formula: C₁₉H₂₂O₇

Purity: 98%

Molecular weight: 362.3738

Ref: IN-DA00BEB6

LL-Z-1640-2

CAS: 253863-19-3

LL-Z-1640-2

Formula: C₁₉H₂₂O₇

Purity: By hplc: 100.0% (Typical Value in Batch COA)

Color and Shape: whitish powder

Molecular weight: 362.37g/mol

Ref: 54-BIL0128

5Z-7-Oxozeaenol

CAS: 253863-19-3

Formula: C₁₉H₂₂O₇

Purity: ≥ 98.0%

Color and Shape: White or off-white solid

Molecular weight: 362.37

Ref: 7W-GL5448

5Z-7-Oxozeaenol

CAS: 253863-19-3

5Z-7-Oxozeaenol: TGF-β-activated kinase 1 inhibitor, IC50 8.1 nM; VEGF-R2 inhibitor, IC50 52 nM; weak MEK1 inhibitor, IC50 411 nM.

Formula: C₁₉H₂₂O₇

Purity: 99%

Color and Shape: Solid

Molecular weight: 362.37

Ref: TM-T14055

(5Z)-7-Oxozeaenol

CAS: 253863-19-3

(5Z)-7-Oxozeaenol is a potent and selective small-molecule inhibitor, primarily characterized as a natural product derived from fungal sources. It specifically targets and inhibits transforming growth factor-beta (TGF-β) type I receptor kinase, also known as activin receptor-like kinase 5 (ALK5), as well as TAO kinases. The inhibition occurs through covalent modification, which results in the suppression of downstream signaling pathways that are crucial in various cellular processes.

Formula: C₁₉H₂₂O₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 362.37 g/mol

Ref: 3D-DKA86319

5Z-7-Oxozeaenol

CAS: 253863-19-3

Purity: 99%

Molecular weight: 362.378

Ref: 10-F979227