CAS 25387-67-1

CAMPTOTHECIN SODIUM SALT

Description:

Camptothecin sodium salt is a water-soluble derivative of camptothecin, a naturally occurring alkaloid derived from the bark of the Camptotheca acuminata tree. This compound is primarily known for its role as an anticancer agent, functioning as a topoisomerase I inhibitor, which interferes with DNA replication and transcription, ultimately leading to cell death in rapidly dividing cancer cells. The sodium salt form enhances its solubility in aqueous solutions, making it more suitable for pharmaceutical formulations. Camptothecin sodium salt exhibits a range of biological activities, including cytotoxicity against various cancer cell lines. Its mechanism of action involves stabilizing the topoisomerase I-DNA complex, preventing the religation of DNA strands, which is crucial for maintaining genomic integrity. Additionally, it has been studied for its potential in combination therapies to enhance the efficacy of other chemotherapeutic agents. However, its clinical use is often limited by issues such as toxicity and the development of drug resistance, necessitating ongoing research into its pharmacological properties and formulation strategies.

Formula: C₂₀H₁₇N₂NaO₅

InChI: InChI=1/C20H18N2O5.Na/c1-2-20(27,19(25)26)14-8-16-17-12(9-22(16)18(24)13(14)10-23)7-11-5-3-4-6-15(11)21-17;/h3-8,23,27H,2,9-10H2,1H3,(H,25,26);/t20-;/m1./s1

InChI key: InChIKey=PBJLMBQVBUDNJL-BDQAORGHSA-N

SMILES: O=C1N2C(C=3C(C2)=CC=4C(N3)=CC=CC4)=CC([C@](C(O)=O)(CC)O)=C1CO.[Na]

Synonyms:

• 1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, sodium salt, (4S)- (1:1)
• 20(S)-Camptothecin sodium salt
• 21,22-Secocamptothecin-21-oic acid, monosodium salt
• 21,22-Secocamptothecin-21-oic acid, monosodium salt (8CI)
• Ai3-62931
• Camptothecin sodium
• Camptothecine sodium
• Indolizino(1,2-b)quinoline-7-acetic acid, alpha-ethyl-9,11-dihydro-alpha-hydroxy-8-(hydroxymethyl)-9-oxo-, monosodium salt, (S)- (9CI)
• Indolizino[1,2-b]quinoline-7-acetic acid, α-ethyl-9,11-dihydro-α-hydroxy-8-(hydroxymethyl)-9-oxo-, monosodium salt, (S)-
• Indolizino[1,2-b]quinoline-7-acetic acid, α-ethyl-9,11-dihydro-α-hydroxy-8-(hydroxymethyl)-9-oxo-, monosodium salt, (αS)-
• Indolizino[1,2-b]quinoline-7-acetic acid, α-ethyl-9,11-dihydro-α-hydroxy-8-(hydroxymethyl)-9-oxo-, sodium salt (1:1), (αS)-
• Nsc-100880
• Sodium Hydride - 2-Hydroxy-2-[8-(Hydroxymethyl)-9-Oxo-9,11-Dihydroindolizino[1,2-B]Quinolin-7-Yl]Butanoic Acid (1:1)
• Sodium camptothecin
• indolizino[1,2-b]quinoline-7-acetic acid, alpha-ethyl-9,11-dihydro-alpha-hydroxy-8-(hydroxymethyl)-9-oxo-, sodium salt, (alphaR)- (1:1)
• sodium (2R)-2-hydroxy-2-[8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl]butanoate
• sodium (4S)-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-olate
• Camptothecin, sodium salt
• 21,22-Secocamptothecin-21-oic acid, monosodium salt 20(S)-camptothecin sodium salt
• camptothecinsodium
• Indolizino[1,2-B]quinoline-7-acetic acid,.alpha.-ethyl- 9,11-dihydro-.alpha.-hydroxy-8-(hydroxymethyl)-9-oxo-,monosodium salt, (S)-
• Irinotecan Impurity 18 HCl
• camptothecin,sodiumsalt
• Indolizino[1,2-b]quinoline-7-acetic acid,a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-, monosodiumsalt, (aS)-
• 20(s)-camptothecinsodiumsalt
• sodium (S)-2-hydroxy-2
• Irinotecan Hydroxyl Acid 18
• CaMphotecin sodiuM
• Fda 1660
• 21,22-secocamptothecin-21-oicacid,monosodiumsalt
• (αS)-α-Ethyl-9,11-dihydro-α-hydroxy-8-(hydroxymethyl)-9-oxoindolizino[1,2-b]quinoline-7-acetic acid sodium salt

Indolizino[1,2-b]quinoline-7-acetic acid,a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-, monosodiumsalt, (aS)-

CAS: 25387-67-1

Formula: C₂₀H₁₇N₂NaO₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 388.3491

Ref: IN-DA00C1KS

Sodium Camptothecin

CAS: 25387-67-1

Sodium Camptothecin

Purity: ≥98%

Molecular weight: 389.36g/mol

Ref: 54-BUP11379

Sodium Camptothecin

CAS: 25387-67-1

Sodium Camptothecin: plant-derived, antitumor, inhibits RNA/DNA synthesis, disrupts viral DNA.

Formula: C₂₀H₁₈N₂NaO₅

Purity: 98.93%

Color and Shape: Solid

Molecular weight: 389.36

Ref: TM-T40179

Sodium camptothecin

CAS: 25387-67-1

Sodium Camptothecin is a cytotoxic drug that inhibits the protein synthesis of cells by binding to the DNA template. It has been shown to be effective against mouse tumor cells, although it also has toxic effects on healthy cells. Sodium Camptothecin is able to bind to polymorphic hydroxyl groups and is an analog of camptothecin. It was also found to have potent antitumor activity in leukemic mice. The physiological effects of sodium camptothecin are unclear, but it appears to inhibit carboxylate metabolism in human serum.

Formula: C₂₀H₁₈N₂O₅·Na

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 389.36 g/mol

Ref: 3D-ABA38767

Sodium camptothecin

CAS: 25387-67-1

Formula: C₂₀H₁₇N₂NaO₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 388.355

Ref: 10-F516596