CAS 25389-94-0

Kanamycin sulfate

Description:

Kanamycin sulfate is an aminoglycoside antibiotic derived from the bacterium Micromonospora kanamycetica. It is primarily used to treat infections caused by certain types of bacteria, particularly those resistant to other antibiotics. Kanamycin sulfate is characterized by its ability to inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit, which disrupts the translation process. This antibiotic is effective against a range of Gram-negative and some Gram-positive bacteria. In its sulfate form, it is more soluble in water, enhancing its bioavailability for therapeutic use. Kanamycin sulfate is typically administered via injection or infusion, and its use is associated with potential side effects, including nephrotoxicity and ototoxicity, necessitating careful monitoring of kidney function and hearing during treatment. Additionally, resistance to kanamycin can develop, making susceptibility testing important in clinical settings. Overall, kanamycin sulfate remains a valuable option in the antibiotic arsenal, particularly for treating serious infections where other treatments may fail.

Formula: C₁₈H₃₆N₄O₁₁·H₂O₄S

InChI: InChI=1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

InChI key: InChIKey=OOYGSFOGFJDDHP-KMCOLRRFSA-N

SMILES: S(=O)(=O)(O)O.O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](N)C[C@H]1N)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O

Synonyms:

• (1R,2S,3S,4R,6R)-4,6-Diamino-3-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 6-amino-6-deoxy-α-L-galactopyranoside sulfate (salt)
• (1S,2R,3R,4S,6R)-4,6-diamino-3-[(6-amino-6-deoxy-alpha-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside sulfate (1:1)
• (1S,2R,4S,6R)-4,6-diamino-3-[(6-amino-6-deoxy-α-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-α-D-glucopyranoside sulfate (salt)
• (2S,3S,4R,5S,6S)-2-(aminomethyl)-6-[(1R,2S,3S,4R,6R)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]tetrahydropyran-3,4,5-triol,sulfuric acid
• 4,6-Diamino-3-[(6-Amino-6-Deoxyhexopyranosyl)Oxy]-2-Hydroxycyclohexyl 3-Amino-2,3-Dideoxyhexopyranoside Sulfate (1:1)
• 4,6-Diamino-3-[(6-Amino-6-Deoxyhexopyranosyl)Oxy]-2-Hydroxycyclohexyl 3-Amino-3-Deoxyhexopyranoside Sulfate (1:1)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:1)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:1) (salt)
• Cantrex
• Cristalomicina
• Enterokanacin
• Kamycin
• Kanabristol
• Kanacedin
• Kanachron
• Kanamycin A monosulfate
• Kanamycin A sulfate
• Kanamycin Mono Sulphate
• Kanamycin Monosulfate
• Kanamycin Monosulfate Salt
• Kanamycin Solution Hybri-Max
• Kanamycin Sulfate
• Kanamycin Sulfate Salt
• Kanamycin Sulfate Usp
• Kanamycin Sulfate White
• Kanamycin, sulfate (1:1) (salt)
• Kanamytrex
• Kanaqua
• Kanasig
• Kanatrol
• Kanescin
• Kanicin
• Kannasyn
• Kantrex
• Kantrexil
• Kantrim
• Kantrox
• Kasmynex
• Kenendomycin
• Klebcil
• Ophtalmokalixan
• Otokalixin
• Resistomycin
• α-L-galactopyranoside, (1R,2S,3S,4R,6R)-4,6-diamino-3-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 6-amino-6-deoxy-, sulfate (1:1) (salt)
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:1) (salt)

Kanamycin Monosulfate

CAS: 25389-94-0

Formula: C₁₈H₃₆N₄O₁₁H₂O₄S

Molecular weight: 484.5 : 98.1

Ref: ST-EA-CP-K6001

Kanamycin A Sulfate

CAS: 25389-94-0

Applications Antibiotic complex produced by Streptomyces kanamyceticus Okami & Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congeners. Antibacterial.
References Ito, et al.: J. Antibiot., 17, 189 (1964), Toda, S., et al.: J. Antibiot., 30, 1002 (1977), Claes, P.J., et al.: Anal. Profiles Drug. Subs., 6, 259 (1977),

Formula: C₁₈H₃₆N₄O₁₁·H₂O₄S

Color and Shape: Neat

Molecular weight: 582.58

Ref: TR-K137500

Kanamycin sulfate

CAS: 25389-94-0

Inhibitor of protein synthesis; aminoglycoside

Formula: C₁₈H₃₈N₄O₁₅S

Color and Shape: White Powder

Molecular weight: 582.58 g/mol

Ref: 3D-AK11349

Kanamycin Monosulphate (KM) extrapure, 750mcg/mg

CAS: 25389-94-0

Formula: C₁₈H₃₆N₄O₁₁·H₂SO₄

Color and Shape: White, Crystalline powder

Molecular weight: 582.60

Ref: SR-99311

Kanamycin Monosulphate (KM) for tissue culture, 750mcg/mg

CAS: 25389-94-0

Formula: C₁₈H₃₆N₄O₁₁·H₂SO₄

Color and Shape: White, Crystalline powder

Molecular weight: 582.60

Ref: SR-76061

Kanamycin Sulfate, Streptomyces kanamyceticus

CAS: 25389-94-0

M02038 - Kanamycin Sulfate, Streptomyces kanamyceticus

Formula: C₁₈H₃₈N₄O₁₅S

Purity: >680 u/mg

Color and Shape: Solid, Crystalline Powder or Powder

Molecular weight: 582.58

Ref: 10-M02038