CAS 2541-37-9

Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16-methyl-, (6α,11β,16α)-

Description:

Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16-methyl-, (6α,11β,16α)-, commonly known as a synthetic corticosteroid, exhibits several notable characteristics. This compound is a derivative of progesterone and is characterized by its structural modifications, including the presence of fluorine atoms and an acetoxy group, which enhance its biological activity and stability. It typically exhibits anti-inflammatory and immunosuppressive properties, making it useful in various therapeutic applications, particularly in treating conditions like asthma, allergies, and autoimmune disorders. The specific stereochemistry indicated by the (6α,11β,16α) configuration plays a crucial role in its pharmacological effects, influencing receptor binding and activity. Additionally, the compound's solubility and stability can vary based on its formulation and the presence of other excipients. As with many corticosteroids, careful consideration of dosage and potential side effects is essential in clinical use, including the risk of adrenal suppression and other systemic effects.

Formula: C₂₄H₃₀F₂O₅

InChI: InChI=1S/C24H30F2O5/c1-12-7-15-16-9-18(25)17-8-14(28)5-6-23(17,4)24(16,26)20(30)10-22(15,3)21(12)19(29)11-31-13(2)27/h5-6,8,12,15-16,18,20-21,30H,7,9-11H2,1-4H3/t12-,15+,16+,18+,20+,21-,22+,23+,24+/m1/s1

InChI key: InChIKey=FHRAHFYXLDXYML-CDACMRRYSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@@H](C(COC(C)=O)=O)[C@H](C)C3)[H])(C[C@H](F)C=4[C@]2(C)C=CC(=O)C4)[H]

Synonyms:

• Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16-methyl-, (6α,11β,16α)-
• Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,21-dihydroxy-16α-methyl-, 21-acetate

Flumethasone Impurity 10

CAS: 2541-37-9

Formula: C₂₄H₃₀F₂O₅

Molecular weight: 436.50

Ref: 4Z-F-7013

Difluocortolone 21-Acetate

Controlled Product

CAS: 2541-37-9

Formula: C₂₄H₃₀F₂O₅

Color and Shape: Neat

Molecular weight: 436.489

Ref: TR-P485920

Diflucortolone-d3 21-Acetate

Controlled Product

CAS: 2541-37-9

Applications Diflucortolone-d3 (D445617) derivative. A glucocorticoid.

Formula: C₂₄H₂₇D₃F₂O₅

Color and Shape: Neat

Molecular weight: 439.51

Ref: TR-D445612

Flumethasone Impurity 10

Controlled Product

CAS: 2541-37-9

Flumethasone Impurity 10 is a synthetic drug product. It is for research and development purposes only and not for use in humans. Flumethasone Impurity 10 is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Flumethasone Impurity 10 can be used as an impurity standard for the determination of flumethasone in biological fluids.

Purity: Min. 95%

Ref: 3D-IF180667

Difluocortolone 21-Acetate

CAS: 2541-37-9

Formula: C₂₄H₃₀F₂O₅

Molecular weight: 436.5

Ref: ST-EA-CP-D115002