CAS 254435-95-5

[D-MeAla]3-[EtVal]4-cyclosporin A

Description:

[D-MeAla]3-[EtVal]4-cyclosporin A is a synthetic derivative of cyclosporin A, which is a cyclic peptide known for its immunosuppressive properties. This compound features modifications in its amino acid sequence, specifically incorporating D-methyl alanine (D-MeAla) and ethyl valine (EtVal) residues. These modifications can enhance the drug's pharmacological profile, potentially improving its efficacy and reducing side effects compared to the parent compound. The structure of this substance includes a cyclic arrangement of amino acids, which contributes to its stability and biological activity. As with other cyclosporins, it functions primarily by inhibiting T-cell activation, making it valuable in organ transplantation and autoimmune disease management. The unique characteristics of [D-MeAla]3-[EtVal]4-cyclosporin A may also influence its solubility, bioavailability, and interaction with cellular targets, which are critical factors in its therapeutic application. Overall, this compound represents a tailored approach to enhancing the properties of traditional immunosuppressants.

Formula: C₆₃H₁₁₃N₁₁O₁₂

Synonyms:

• Debio-025
• Unil-025

Alisporivir

CAS: 254435-95-5

Alisporivir (Debio-025) is a cyclophilin A inhibitor that disrupts the interaction between CypA and NS5A. HCV activity in vivo and in vitro.

Formula: C₆₃H₁₁₃N₁₁O₁₂

Purity: 99.95%

Color and Shape: Solid

Molecular weight: 1216.64

Ref: TM-T14180

Alisporivir

CAS: 254435-95-5

Alisporivir is an investigational antiviral agent, which is a synthetic derivative of cyclosporine A. It originates from the structural modification of naturally occurring cyclosporines, specifically designed to retain potent antiviral activity while minimizing immunosuppressive effects. Its mode of action involves the inhibition of cyclophilin, an essential cellular protein that facilitates the replication of hepatitis C virus (HCV) by interacting with viral proteins. By binding to cyclophilin, alisporivir disrupts this interaction, effectively halting the viral replication process.

Formula: C₆₃H₁₁₃N₁₁O₁₂

Purity: Min. 95%

Molecular weight: 1,216.6 g/mol

Ref: 3D-EKA43595