CAS 254452-88-5

6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, calcium salt (2:1), (3S,5R,6E)-

Description:

6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, calcium salt (2:1), (3S,5R,6E)- is a complex organic compound characterized by its unique structural features, including a heptenoic acid backbone and a quinoline moiety. The presence of multiple functional groups, such as hydroxyl (-OH) groups, contributes to its potential reactivity and solubility properties. The calcium salt form indicates that the compound can form ionic bonds with calcium ions, which may enhance its stability and bioavailability. The stereochemistry, denoted by (3S,5R,6E), suggests specific spatial arrangements of atoms that can influence the compound's biological activity and interaction with other molecules. This compound may exhibit pharmacological properties, making it of interest in medicinal chemistry. Its fluorophenyl and cyclopropyl substituents could also impart unique electronic and steric characteristics, affecting its overall behavior in chemical reactions and biological systems. Further studies would be necessary to fully elucidate its properties and potential applications.

Formula: C₂₅H₂₄FNO₄Ca

InChI: InChI=1S/C25H24FNO4.Ca/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31);/b12-11+;/t18-,19-;/m0./s1

InChI key: InChIKey=AMUDYCAFPCQTAZ-RPQBTBOMSA-N

SMILES: C(=C/[C@@H](C[C@@H](CC(O)=O)O)O)\C1=C(C2=C(N=C1C3CC3)C=CC=C2)C4=CC=C(F)C=C4.[Ca]

Synonyms:

• 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, calcium salt (2:1), (3S,5R,6E)-
• ent-NK-104

Pitavastatin Enantiomer

CAS: 254452-88-5

Compounds containing a quinoline or isoquinoline ring-system, whether or not hydrogenated, not further fused, excluding drugs and pesticides

Formula: CaC₂₅H₂₃FNO₄

Color and Shape: White Fine Powder

Molecular weight: 880.28481

Ref: 45-1544745

(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid Calcium Salt

CAS: 254452-88-5

Formula: C₂₅H₂₄CaFNO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 461.5388

Ref: IN-DA00C2ZM

(3S,5R)-Pitavastatin Calcium Salt

CAS: 254452-88-5

Formula: C₂₅H₂₃FNO₄·5Ca

Color and Shape: White To Off-White Solid

Molecular weight: 420.46 0.5*40.08

Ref: 4Z-P-6422

Calcium (3S,5R,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate

CAS: 254452-88-5

Calcium (3S,5R,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate

Purity: 98%

Molecular weight: 881g/mol

Ref: 54-IN12847

Pitavastatin (3S,5R)-Isomer

CAS: 254452-88-5

Formula: C₂₅H₂₃FNO₄(Ca)

Molecular weight: 420.46 : 1/2(40.1)

Ref: ST-EA-CP-P23004

(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid Calcium Salt

Controlled Product

CAS: 254452-88-5

Applications (3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid Calcium Salt is the 3S,5R- Isomer of Pitavastatin (P531000), a HMG CoA reductase inhibitor and an antilipemic agent.
References Suzukim M., et al.: Bioorg. Med. Chem., 9, 2977 (1999); Yen, H., et al.: J. Clin. Invest., 98, 1253 (1996); Zou, Y., et al.: J. Biol. Chem., 274, 9760 (1999); Sun, X., et al.: Cancer Res., et al.: 61, 3382 (2001); Ladas, E.J., et al.: Clin. Oncol., 22, 517 (2004);

Formula: C₂₅H₂₄FNO₄Ca

Color and Shape: Neat

Molecular weight: 440.49

Ref: TR-C988610

Pitavastatin 3S,5R isomer calcium

CAS: 254452-88-5

Pitavastatin 3S,5R isomer Calcium Salt is a potent inhibitor of cholesterol biosynthesis. It is marketed as the hemihydrate form under the trade name Pravacol and is used in the treatment of type 2 diabetes. Pitavastatin 3S,5R isomer Calcium Salt inhibits cholesterol biosynthesis by blocking HMG-CoA reductase, which converts 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate (MVA). The active metabolite, pitavastatin, binds to the regulatory region of HMG-CoA reductase and prevents it from converting MVA to HMG-CoA. This reduces the pool of HMG-CoA available for conversion to cholesterol. The inhibition of this enzyme slows down the production of cholesterol and decreases blood levels. It has been approved for use in adults with type 2 diabetes and for lowering high

Formula: (C₂₅H₂₄FNO₄)₂•Ca

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 880.98 g/mol

Ref: 3D-IP145451

(3S,5R)-Pitavastatin calcium

CAS: 254452-88-5

(3S,5R)-Pitavastatin calcium is the enantiomer of Pitavastatin which is a potent HMG-CoA reductase inhibitor.

Formula: C₂₅H₂₆CaFNO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 463.562

Ref: TM-T10130