CAS 254740-64-2

4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-[1,1'-biphenyl]-2-sulfonamide

Description:

The chemical substance with the name "4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-[1,1'-biphenyl]-2-sulfonamide" and CAS number "254740-64-2" is a complex organic compound characterized by its unique structural features, including a biphenyl core, sulfonamide functional group, and a diazaspiro moiety. This compound exhibits potential biological activity, which may be attributed to its intricate arrangement of functional groups that can interact with various biological targets. The presence of the isoxazole ring suggests possible applications in medicinal chemistry, particularly in the development of pharmaceuticals. Additionally, the butyl and ethoxymethyl substituents contribute to its lipophilicity, potentially influencing its pharmacokinetic properties. The compound's synthesis and characterization would typically involve advanced organic chemistry techniques, and its stability, solubility, and reactivity would be of interest in both research and application contexts. Overall, this substance represents a class of compounds that may have significant implications in drug discovery and development.

Sparsentan (RE-021)

CAS: 254740-64-2

Formula: C₃₂H₄₀N₄O₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 592.7488

Ref: IN-DA00C2P2

4'-((2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-[1,1'-biphenyl]-2-sulfonamide

CAS: 254740-64-2

4'-((2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-[1,1'-biphenyl]-2-sulfonamide

Purity: 98%

Molecular weight: 592.75g/mol

Ref: 54-OR1023038

Sparsentan (RE-021)

CAS: 254740-64-2

Formula: C₃₂H₄₀N₄O₅S

Color and Shape: White To Off-White Solid

Molecular weight: 592.76

Ref: 4Z-S-059002

Sparsentan

CAS: 254740-64-2

Sparsentan

Purity: ≥95%

Molecular weight: 592.75g/mol

Ref: 54-BUP15364

Sparsentan

CAS: 254740-64-2

Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM,

Formula: C₃₂H₄₀N₄O₅S

Purity: 97.94% - 98.69%

Color and Shape: Solid

Molecular weight: 592.75

Ref: TM-T5355

RE 201

Controlled Product

CAS: 254740-64-2

Formula: C₃₂H₄₀N₄O₅S

Color and Shape: Neat

Molecular weight: 592.749

Ref: TR-R129300

RE-021-d9

Controlled Product

CAS: 254740-64-2

Applications Isotope labelled RE 201 is used an Endothelin A receptor antagonist used in the treatment of hypertension.
References Murugesan, N. et al.: J. Med. Chem., 48, 171 (2005);

Formula: C₃₂D₉H₃₁N₄O₅S

Color and Shape: Neat

Molecular weight: 601.804

Ref: TR-R129302