CAS 254753-54-3: Monastrol

Description:Monastrol is a small molecule inhibitor primarily known for its role in disrupting the function of kinesin-5, a motor protein involved in mitosis. It is characterized by its ability to inhibit cell division, making it a subject of interest in cancer research. Monastrol is typically described as a white to off-white solid with moderate solubility in organic solvents. Its molecular structure features a unique arrangement that allows it to selectively bind to the kinesin-5 motor domain, thereby preventing the proper functioning of this protein during the mitotic process. This inhibition leads to the disruption of spindle formation and ultimately results in cell cycle arrest. Monastrol has been utilized in various studies to explore its potential as a therapeutic agent in cancer treatment, particularly in targeting rapidly dividing cells. Additionally, its specificity for kinesin-5 makes it a valuable tool for studying the mechanics of cell division and the role of motor proteins in cellular processes.

Formula:C₁₄H₁₆N₂O₃S

InChI:InChI=1/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)

Synonyms:
ethyl (4S)-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
ethyl (4R)-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Ethyl 4-(3-Hydroxyphenyl)-6-Methyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
5-Pyrimidinecarboxylicacid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-, ethyl ester
6-Methyl-4-(3-hydroxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylicacid ethyl ester

Found 4 products.

Product data	Purity	Price range	Estimated delivery
MONASTROL REF: IN-DA00BC6LCAS: 254753-54-3	98%	To inquire	Thu 17 Apr 25
Monastrol REF: 7W-GP0690CAS: 254753-54-3	- - -	To inquire	Mon 21 Apr 25
(S)-Monastrol REF: TM-T4649CAS: 254753-54-3	98%	To inquire	Mon 21 Apr 25
Monastrol REF: 3D-EKA75354CAS: 254753-54-3	Min. 95%	To inquire	Thu 29 May 25