CAS 25514-31-2

Bruceine A

Description:

Bruceine A is a natural compound classified as a triterpenoid, specifically a type of limonoid, which is derived from the seeds of the Brucea javanica plant. It is known for its complex molecular structure, which includes multiple rings and functional groups that contribute to its biological activity. Bruceine A exhibits a range of pharmacological properties, including antitumor, anti-inflammatory, and antimicrobial effects, making it a subject of interest in medicinal chemistry and pharmacology. The compound has been studied for its potential therapeutic applications, particularly in cancer treatment, due to its ability to induce apoptosis in cancer cells. Additionally, Bruceine A's mechanism of action may involve the modulation of various signaling pathways, although further research is necessary to fully elucidate its effects and potential uses. Its unique chemical characteristics and biological activities highlight the importance of natural products in drug discovery and development.

Formula: C₂₆H₃₄O₁₁

InChI: InChI=1S/C26H34O11/c1-10(2)6-15(28)37-18-20-25-9-35-26(20,23(33)34-5)21(31)17(30)19(25)24(4)8-13(27)16(29)11(3)12(24)7-14(25)36-22(18)32/h10,12,14,17-21,29-31H,6-9H2,1-5H3/t12-,14+,17+,18+,19+,20+,21-,24-,25+,26-/m0/s1

InChI key: InChIKey=LPZSTPCYWWRQFU-VILODJCFSA-N

SMILES: C(OC)(=O)[C@]12[C@]3([C@]4([C@@]([C@]5(C)[C@@](C[C@]4(OC(=O)[C@@H]3OC(CC(C)C)=O)[H])(C(C)=C(O)C(=O)C5)[H])([C@@H](O)[C@@H]1O)[H])CO2)[H]

Synonyms:

• 2H-3,11cβ-(Epoxymethano)phenanthro[10,1-bc]pyran-3α(1H)-carboxylic acid, 3a,4,5,6aβ,7,7aα,10,11,11a,11bα-decahydro-1β,2α,4β,9-tetrahydroxy-8,11aβ-dimethyl-5,10-dioxo-, methyl ester, 4-isovalerate
• Brucein A
• Bruceine A
• Dihydrobrusatol
• Methyl (11beta,12alpha,15beta)-3,11,12-trihydroxy-15-[(3-methylbutanoyl)oxy]-2,16-dioxo-13,20-epoxypicras-3-en-21-oate
• NSC 310616
• Picras-3-En-21-Oic Acid, 13,20-Epoxy-3,11,12-Trihydroxy-15-(3-Methyl-1-Oxobutoxy)-2,16-Dioxo-, Methyl Ester, (11Beta,12Alpha,15Beta)-
• Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-(3-methyl-1-oxobutoxy)-2,16-dioxo-, methyl ester, (11β,12α,15β)-

Bruceine A

CAS: 25514-31-2

Formula: C₂₆H₃₄O₁₁

Purity: %

Color and Shape: Solid

Molecular weight: 522.5416

Ref: IN-DA00BF2L

Bruceine A

CAS: 25514-31-2

Formula: C₂₆H₃₄O₁₁

Molecular weight: 522.55

Ref: 7W-GY6832

Bruceine A

CAS: 25514-31-2

Bruceine A

Purity: ≥98%

Molecular weight: 522.54g/mol

Ref: 54-BUP03942

Bruceine A

CAS: 25514-31-2

Bruceine A has antibabesial activity, it can inhibit the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration and kill the parasites within 24 hr at a concentration of 25 nM; it show strong antitrypanosomal activities with IC(50) values in the range of 2.9-17.8nM. Bruceine A has anthelmintic activity, it exhibits significant activity against Dactylogyrus intermedius with EC(50) values of 0.49 mg/L. Bruceine A exhibits NF-κB p65 inhibition, and cytotoxic potential against HT-29, HeLa, and HL-60 cells .

Formula: C₂₆H₃₄O₁₁

Purity: 95%~99%

Molecular weight: 522.547

Ref: BP-BP3089

Bruceine A

CAS: 25514-31-2

Bruceine A, a quassinoid from Brucea javanica fruit, may treat canine babesiosis.

Formula: C₂₆H₃₄O₁₁

Purity: 99.13% - 99.85%

Color and Shape: Solid

Molecular weight: 522.54

Ref: TM-T2S2046

Bruceantin A

Controlled Product

CAS: 25514-31-2

Applications Bruceantin A acts as an anti-babesial quassinoid, extracted from the fruits of Brucea javanica, also an effective anti-trypanosomal agent in vitro. Cytotoxic agent.
References Bawm, S. et al.: Vet. Parasitol., 158, 288 (2008); Elkhateeb, A, et al.: Nat. Prod. Comm., 3, 145 (2008);

Formula: C₂₆H₃₄O₁₁

Color and Shape: Neat

Molecular weight: 522.542

Ref: TR-B689315

Bruceine A

CAS: 25514-31-2

Bruceine A is a bioactive quassinoid compound, which is derived from the seeds of Brucea javanica, a plant native to Southeast Asia. As a natural product, Bruceine A exhibits significant pharmacological activities, primarily due to its ability to modulate various biological pathways.

Purity: Min. 95%

Ref: 3D-FB74247