CAS 25526-93-6: 3′-Fluorothymidine

Description: 3′-Fluorothymidine, also known as F-ara-T, is a nucleoside analog of thymidine, characterized by the presence of a fluorine atom at the 3′ position of the sugar moiety. This modification alters its biochemical properties, making it a subject of interest in antiviral and anticancer research. The compound exhibits antiviral activity, particularly against certain strains of viruses, including HIV, by interfering with viral replication. Its mechanism of action involves incorporation into viral DNA, leading to chain termination during DNA synthesis. Additionally, 3′-Fluorothymidine has been studied for its potential use in cancer therapy due to its ability to inhibit DNA polymerases. The substance is typically administered in a phosphorylated form to enhance its bioavailability and efficacy. In terms of physical properties, it is a white to off-white solid, soluble in water and organic solvents, and has a relatively stable structure under physiological conditions. As with many nucleoside analogs, careful consideration of dosage and potential side effects is essential in therapeutic applications.

Formula: C₁₀H₁₃FN₂O₄

InChI: InChI=1S/C10H13FN2O4/c1-5-3-13(10(16)12-9(5)15)8-2-6(11)7(4-14)17-8/h3,6-8,14H,2,4H2,1H3,(H,12,15,16)/t6-,7+,8+/m0/s1

InChI key: InChIKey=UXCAQJAQSWSNPQ-XLPZGREQSA-N

SMILES: O=C1NC(=O)N(C=C1C)C2OC(CO)C(F)C2

Synonyms:

• 1-(2,3-dideoxy-3-fluoropentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• 1-(3'-Deoxy-3'-fluoro-beta-D-pentofuranosyl)thymine
• 1-(3′-Deoxy-3′-fluoro-β-<span class="text-smallcaps">D</span>-pentofuranosyl)thymine
• 1-[(3xi)-2,3-dideoxy-3-fluoro-beta-D-glycero-pentofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione
• 3'-Deoxy-3'-fluorothymidine(ALOVUDINE)
• 3'-Fluoro-2',3'-Dideoxythymidine
• 3'-Fluoro-3'-Deoxythymidine
• 3'-Fluoro-thymidine
• 3'-Fluorodeoxythymidine
• 3'-Fluorothymidine
• 3′-Fluoro-2′,3′-dideoxythymidine
• Alovudine
• Cl 184824
• FLT
• Miv 310
• NSC 140025
• Thymidine, 3'-deoxy-3'-fluoro-
• 3′-Deoxy-3′-fluorothymidine
• 1-(3′-Deoxy-3′-fluoro-β-D-pentofuranosyl)thymine

Thymidine, 3'-deoxy-3'-fluoro-

CAS: 25526-93-6

• Formula: C₁₀H₁₃FN₂O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 244.2196

1-((2R,4S,5R)-4-Fluoro-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione

CAS: 25526-93-6

• Purity: 98%
• Molecular weight: 244.22g/mol

3''-Deoxy-3''-fluorothymidine

CAS: 25526-93-6

• Formula: C₁₀H₁₃FN₂O₄
• Purity: ≥ 97.0%
• Color and Shape: White to off-white powder or crystals
• Molecular weight: 244.22

3'-Fluoro-3'-deoxythymidine

CAS: 25526-93-6

• Purity: 98%
• Molecular weight: 244.2220001220703

Alovudine

CAS: 25526-93-6

3'-Fluoro-3'-deoxythymidine (3'-Deoxy-3'-fluorothymidine) is a marker of DNA synthesis,which is less susceptible to inflammatory changes than …

• Formula: C₁₀H₁₃FN₂O₄
• Purity: 99.69%
• Color and Shape: Less Solid Colourless Solid
• Molecular weight: 244.22

3'-Deoxy-3'-fluorothymidine

CAS: 25526-93-6

3'-Deoxy-3'-fluorothymidine is a nucleoside analog that is used to diagnose and treat cancer. It is …

• Formula: C₁₀H₁₃FN₂O₄
• Purity: Min. 97 Area-%
• Color and Shape: White Off-White Powder
• Molecular weight: 244.22 g/mol

3’-Deoxy-3’-fluoro Thymidine

CAS: 25526-93-6

Applications An antiviral agent. References Hoffman, B., et al.: J. Med. Chem., 43, 4151 (2000), …

• Formula: C₁₀H₁₃FN₂O₄
• Color and Shape: Neat
• Molecular weight: 244.22