P-glycoprotein (P-gp) inhibitor 17, identified by its CAS number 2556388-58-8, is a chemical compound that plays a significant role in pharmacology, particularly in the context of drug absorption and resistance. P-glycoprotein is a membrane protein that functions as a drug efflux pump, actively transporting various substances out of cells, which can limit the effectiveness of certain medications. Inhibitors like P-gp inhibitor 17 are designed to block this efflux mechanism, thereby enhancing the bioavailability of co-administered drugs that are substrates of P-gp. The characteristics of this compound typically include its molecular structure, which may feature specific functional groups that confer its inhibitory activity, as well as its solubility, stability, and potential interactions with other drugs. Additionally, the compound's pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, are crucial for understanding its therapeutic potential and safety profile. Research into P-gp inhibitors continues to be important for improving drug delivery and overcoming multidrug resistance in various diseases, including cancer.

P-gp inhibitor 17

2556388-58-8: P-glycoprotein (P-gp) inhibitor 17, identified by its CAS number 2556388-58-8, is a chemical compound that plays a significant role in pharmacology, particularly in the context of drug absorption and resistance. P-glycoprotein is a membrane protein that functions as a drug efflux pump, actively transporting various substances out of cells, which can limit the effectiveness of certain medications. Inhibitors like P-gp inhibitor 17 are designed to block this efflux mechanism, thereby enhancing the bioavailability of co-administered drugs that are substrates of P-gp. The characteristics of this compound typically include its molecular structure, which may feature specific functional groups that confer its inhibitory activity, as well as its solubility, stability, and potential interactions with other drugs. Additionally, the compound's pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, are crucial for understanding its therapeutic potential and safety profile. Research into P-gp inhibitors continues to be important for improving drug delivery and overcoming multidrug resistance in various diseases, including cancer.

<p>P-gp Inhibitor 17 (compound 2g), a potent inhibitor, directly interacts with the transmembrane domain of P-gp. This compound is useful for studying P-gp-mediated multidrug resistance in tumor cells [1].</p>

CAS 2556388-58-8

P-gp inhibitor 17

P-gp inhibitor 17

Ref: TM-T87138