CAS 2557-49-5

Diflorasone

Description:

Diflorasone is a synthetic corticosteroid primarily used for its anti-inflammatory and immunosuppressive properties. It is characterized by its potent glucocorticoid activity, making it effective in treating various dermatological conditions, such as eczema and psoriasis. The chemical structure of diflorasone includes fluorine atoms, which enhance its anti-inflammatory efficacy and reduce the risk of systemic side effects compared to other corticosteroids. It is typically formulated as a topical ointment or cream, allowing for localized treatment with minimal systemic absorption. The substance is known for its ability to inhibit the release of inflammatory mediators and modulate immune responses. As with other corticosteroids, prolonged use can lead to potential side effects, including skin thinning and local irritation. Therefore, it is essential to use diflorasone under medical supervision, adhering to prescribed dosages and treatment durations to minimize adverse effects while maximizing therapeutic benefits.

Formula: C₂₂H₂₈F₂O₅

InChI: InChI=1/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1

InChI key: InChIKey=WXURHACBFYSXBI-XHIJKXOTSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@@H](C)C3)[H])(C[C@H](F)C=4[C@]2(C)C=CC(=O)C4)[H]

Synonyms:

• (6Alpha,11Beta,16Beta)-6,9-Difluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• (6α,11β,16β)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 6alpha,9-Difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
• Diflorason
• Diflorasona
• Diflorasona [INN-Spanish]
• Diflorasone [INN:BAN]
• Diflorasonum
• Diflorasonum [INN-Latin]
• Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16β)-
• Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,17,21-trihydroxy-16β-methyl-
• Unii-T2Dhj9645W
• Diflorasone
• (6s,8s,9s,10s,11s,13s,14s,16s,17r)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
• (6α,11β,16β)-6,9-Difluoro-11,17,21-trihydroxy-16-Methyl-pregna-1,4-diene-3,20-dione
• Diflorasone USP/EP/BP
• Difloasone
• (6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
• 11β,17α,21-trihydroxy-6α,9α-difluoro-16β-methylpregna-1,4-diene-3,20-dione
• (6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

Diflorasone

CAS: 2557-49-5

Diflorasone

Purity: ≥98%

Molecular weight: 410.45g/mol

Ref: 54-BUP10531

Diflorasone

CAS: 2557-49-5

Formula: C₂₂H₂₈F₂O₅

Color and Shape: White To Off-White Solid

Molecular weight: 410.46

Ref: 4Z-D-151001

Diflorasone-d4

CAS: 2557-49-5

Formula: C₂₂H₂₄D₄F₂O₅

Molecular weight: 414.48

Ref: 4Z-D-151016

Diflorasone

CAS: 2557-49-5

Diflorasone

Purity: 99%

Molecular weight: 410.45g/mol

Ref: 54-PC109061

Diflorasone

CAS: 2557-49-5

Formula: C₂₂H₂₈F₂O₅

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 410.46

Ref: 3B-D6249

Diflorasone

Controlled Product

CAS: 2557-49-5

Formula: C₂₂H₂₈F₂O₅

Color and Shape: Neat

Molecular weight: 410.45

Ref: 86-MM3529.01

Diflorasone

CAS: 2557-49-5

Diflorasone is a synthetic glucocorticoid. It has anti-inflammatory and immunosuppressive effects by acting on gene expression.

Formula: C₂₂H₂₈F₂O₅

Purity: 99.02% - 99.92%

Color and Shape: Solid

Molecular weight: 410.45

Ref: TM-T2548

Diflorasone

Controlled Product

CAS: 2557-49-5

Applications An anti-inflammatory and anti-itching corticosteroid usually present in topical creams.
References Pedemonte, N., et al.: Am. J. Physiol., 298, C866 (2010),

Formula: C₂₂H₂₈F₂O₅

Color and Shape: Neat

Molecular weight: 410.45

Ref: TR-D445495

Diflorasone

Controlled Product

CAS: 2557-49-5

Diflorasone is a synthetic corticosteroid with anti-inflammatory properties that are similar to those of betamethasone. It is also used to treat skin diseases, such as inflammatory skin diseases and psoriasis. Diflorasone has been shown to inhibit the growth of cells in vitro by binding to the fatty acid receptors on cell membranes and preventing the binding of arachidonic acid. This prevents the production of prostaglandin E2, which is a mediator of inflammation. Diflorasone has also been shown to exhibit anti-cancer effects in animal models and inhibits tumor growth by blocking cell cycle progression at G1 phase and inducing apoptosis.

Formula: C₂₂H₂₈F₂O₅

Purity: Min. 95%

Molecular weight: 410.45 g/mol

Ref: 3D-FD21845