CAS 255721-52-9

Dendroaspis Natriuretic Peptide

Description:

Dendroaspis Natriuretic Peptide (DNP) is a peptide derived from the venom of the black mamba snake (Dendroaspis polylepis). It is characterized by its role as a potent vasodilator and natriuretic agent, influencing cardiovascular and renal functions. DNP is known for its ability to lower blood pressure and promote the excretion of sodium, which can have therapeutic implications in conditions like hypertension and heart failure. The peptide's structure typically consists of a sequence of amino acids that contribute to its biological activity, including receptor binding and signaling pathways. DNP operates through the activation of specific receptors, leading to increased intracellular cyclic GMP levels, which mediate its physiological effects. Its unique origin and function make it a subject of interest in pharmacological research, particularly in the development of novel treatments for cardiovascular diseases. As with many peptides, stability and delivery methods are critical factors in its potential therapeutic applications.

Dendroaspis Natriuretic Peptide

CAS: 255721-52-9

The 38 amino acid peptide DNP, which has been originally isolated from the venom of the green mamba snake (Dendroaspis angusticeps), shares structural homology with the family of natriuretic peptides. DNP contains a 17 amino acid disulfide ring similar to ANP, BNP, and CNP, which mediate biological actions through particulate guanylyl cyclase receptors and generation of guanosine monophosphate (cGMP).

Formula: C₁₈₀H₂₈₂N₅₆O₅₆S₂

Purity: > 95%

Color and Shape: White Whitish Powder

Molecular weight: 4190.69

Ref: 01-4033517