CAS 255730-18-8

Artemisone

Description:

Artemisone is a synthetic derivative of artemisinin, a compound originally derived from the sweet wormwood plant, Artemisia annua, known for its antimalarial properties. With the CAS number 255730-18-8, Artemisone exhibits a unique chemical structure that enhances its efficacy against malaria parasites, particularly in resistant strains. It is characterized by its ability to generate reactive oxygen species upon activation, which contributes to its antimalarial activity. Artemisone has shown promising results in preclinical studies, demonstrating a favorable pharmacokinetic profile, including good oral bioavailability and a relatively long half-life. Additionally, it has been investigated for its potential to treat other parasitic infections and may possess anti-inflammatory properties. The compound is typically studied in the context of drug development for malaria treatment, with ongoing research aimed at optimizing its therapeutic potential and minimizing side effects. As with any pharmaceutical agent, understanding its mechanism of action, safety profile, and efficacy in clinical settings is crucial for its application in medicine.

Formula: C₁₉H₃₁NO₆S

InChI: InChI=1S/C19H31NO6S/c1-12-4-5-15-13(2)16(20-8-10-27(21,22)11-9-20)23-17-19(15)14(12)6-7-18(3,24-17)25-26-19/h12-17H,4-11H2,1-3H3/t12-,13-,14+,15+,16-,17-,18-,19-/m1/s1

InChI key: InChIKey=FDMUNKXWYMSZIR-NQWKWHCYSA-N

SMILES: C[C@@H]1[C@]2([C@]34[C@](O[C@H]1N5CCS(=O)(=O)CC5)(O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])[H])[H]

Synonyms:

• 10a-[4'-(S,S-Dioxothiomorpholin-1'-yl)]-10-deoxodihydroartemisinin
• Artemifone
• Artemisone
• Bay 44-9585
• Thiomorpholine, 4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]-, 1,1-dioxide

Artemisone

CAS: 255730-18-8

Artemisone (BAY 44-9585) is a potent and semi-synthetic antimalarial, inhibits P.

Formula: C₁₉H₃₁NO₆S

Purity: 99.9%

Color and Shape: Solid

Molecular weight: 401.52

Ref: TM-T14324

Artemisone

CAS: 255730-18-8

Artemisone

Purity: ≥98%

Molecular weight: 401.52g/mol

Ref: 54-BUP08982

4-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-Trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)thiomorpholine 1,1-dioxide

Controlled Product

CAS: 255730-18-8

Formula: C₁₉H₃₁NO₆S

Color and Shape: Neat

Molecular weight: 401.517

Ref: TR-M567310

4-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-Trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)thiomorpholine 1,1-dioxide-3,3,5,5-d4

Controlled Product

CAS: 255730-18-8

Formula: C₁₉H₃₁NO₆S

Color and Shape: Neat

Molecular weight: 405.5

Ref: TR-M567312

Artemisone

CAS: 255730-18-8

Artemisone is a sesquiterpene lactone that has been shown to have significant cytotoxicity against cancer cells, such as K562 cells. It is also an inhibitor of the P-glycoprotein (P-gp) transporter, which may make it useful for treating infectious diseases and drug interactions. Artemisone has also been shown to inhibit the activity of recombinant cytochrome P450 enzymes in vitro. This inhibition could be used to study the biological properties of this enzyme system. Artemisone also inhibits the growth of bacteria, including methicillin-resistant Staphylococcus aureus and Streptococcus pneumoniae. Artemisone has been shown to have anti-inflammatory properties in vitro and has been shown to inhibit prostaglandin synthesis in vivo.

Formula: C₁₉H₃₁NO₆S

Purity: Min. 95%

Molecular weight: 401.52 g/mol

Ref: 3D-FKA73018