CAS 2568273-83-4

2,6-Piperidinedione, 3-[5-[trans-4-[4-[4-[3-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-2-pyrimidinyl]-1-piperidinyl]cyclohexyl]-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl]-

Description:

2,6-Piperidinedione, 3-[5-[trans-4-[4-[4-[3-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-2-pyrimidinyl]-1-piperidinyl]cyclohexyl]-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl]- is a complex organic compound characterized by its multi-cyclic structure and various functional groups. This substance features a piperidinedione core, which is a bicyclic compound known for its potential biological activity. The presence of multiple nitrogen-containing rings, such as pyridazine and pyrimidine, suggests that it may exhibit interesting pharmacological properties. Additionally, the compound includes amino and hydroxy groups, which can enhance solubility and reactivity, potentially influencing its interaction with biological targets. Its intricate structure indicates that it may be a candidate for research in medicinal chemistry, particularly in the development of new therapeutic agents. However, detailed studies would be necessary to fully elucidate its properties, including solubility, stability, and biological activity. As with many complex organic compounds, safety and handling precautions should be observed due to potential toxicity or reactivity.

Formula: C₄₄H₅₁N₁₁O₄

Synonyms:

• 2,6-Piperidinedione, 3-[5-[trans-4-[4-[4-[3-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-2-pyrimidinyl]-1-piperidinyl]cyclohexyl]-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl]-

PROTAC SMARCA2/4-degrader-31

CAS: 2568273-83-4

PROTAC SMARCA2/4-degrader-31 (Compound I-280) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It effectively degrades SMARCA2 in A549 cells and SMARCA4 in MV411 cells, both with a degradation concentration (DC50) of less than 100 nM.

Formula: C₄₄H₅₁N₁₁O₄

Color and Shape: Solid

Molecular weight: 797.95

Ref: TM-T89934