CAS 25696-60-0

Tauro-β-muricholic acid

Description:

Tauro-β-muricholic acid is a bile acid derivative that plays a significant role in the metabolism of lipids and the regulation of cholesterol levels in the body. It is formed from the conjugation of β-muricholic acid with taurine, which enhances its solubility and biological activity. This compound is primarily found in the bile of certain rodents and is involved in the emulsification and absorption of dietary fats. Tauro-β-muricholic acid exhibits unique properties, such as the ability to activate specific nuclear receptors, which can influence metabolic pathways and energy homeostasis. Additionally, it has been studied for its potential effects on gut microbiota and its implications in metabolic disorders. The compound is characterized by its amphipathic nature, allowing it to interact with both hydrophilic and hydrophobic environments, which is crucial for its function in digestion. Overall, tauro-β-muricholic acid is an important molecule in the context of bile acid signaling and metabolic regulation.

Formula: C₂₆H₄₅NO₇S

InChI: InChI=1S/C26H45NO7S/c1-15(4-7-21(29)27-12-13-35(32,33)34)17-5-6-18-22-19(9-11-25(17,18)2)26(3)10-8-16(28)14-20(26)23(30)24(22)31/h15-20,22-24,28,30-31H,4-14H2,1-3H3,(H,27,29)(H,32,33,34)/t15-,16-,17-,18+,19+,20+,22+,23+,24-,25-,26-/m1/s1

InChI key: InChIKey=XSOLDPYUICCHJX-UZUDEGBHSA-N

SMILES: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCC(NCCS(=O)(=O)O)=O)C)(CC4)[H])[H])([C@@H](O)[C@@H](O)[C@@]1(C[C@H](O)CC2)[H])[H])[H]

Synonyms:

• 2-[[(3α,5β,6β,7β)-3,6,7-Trihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic acid
• Cholane, ethanesulfonic acid deriv.
• Taurine, N-(3α,6β,7β-trihydroxy-5β-cholan-24-oyl)-
• Taurine,N-(3a,6b,7b-trihydroxy-5b-cholan-24-oyl)- (8CI)
• Tauro-b-muricholate
• Tauro-b-muricholic acid
• Ethanesulfonic acid, 2-[[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-

β-Tauromuricholic Acid

CAS: 25696-60-0

Formula: C₂₆H₄₅NO₇S

Molecular weight: 515.71

Ref: 4Z-C-5777

Tauro-β-muricholic acid

CAS: 25696-60-0

Tauro-β-muricholic acid (TβMCA), a trihydroxylated bile acid, acts as a competitive and reversible FXR antagonist (IC 50 = 40 μM) and exhibits antiapoptotic

Formula: C₂₆H₄₅NO₇S

Purity: 98%

Color and Shape: Solid

Molecular weight: 515.7

Ref: TM-T81030

Tauro-β-muricholic Acid Sodium Salt

CAS: 25696-60-0

Formula: C₂₆H₄₄NO₇S·Na

Molecular weight: 514.70 22.99

Ref: 4Z-C-5748

β-Tauromuricholic-d5 Acid

CAS: 145022-92-0, 25696-60-0

Formula: C₂₆H₄₀D₅NO₇S

Molecular weight: 520.74

Ref: 4Z-C-5778

Tauro-β-muricholic Acid Sodium Salt

Controlled Product

CAS: 25696-60-0

Stability Hygroscopic
Applications Tauro-β-muricholic Acid Sodium Salt is the salt form of Tauro-α-muricholic Acid which is a bile acid released by the liver and is typically used in cholestasis studies.
References Yang, L. et al.: Chem. Res. Toxicol., 21, 2280 (2008); Holm, R. et al.: Phys. Chem. Chem. Phys., 11, 5070 (2009);

Formula: C₂₆H₄₄NO₇S·Na

Color and Shape: Neat

Molecular weight: 515.70

Ref: TR-T009135

Tauro-b-muricholic Acid-d4 Sodium Salt

Controlled Product

CAS: 25696-60-0

Stability Hygroscopic
Applications Sodium salt of Tauro-α-muricholic Acid is a labeled bile acid released by the liver and is typically used in cholestasis studies.
References Yang, L. et al.: Chem. Res. Toxicol., 21, 2280 (2008); Holm, R. et al.: Phys. Chem. Chem. Phys., 11, 5070 (2009);

Formula: C₂₆H₄₀D₄NNaO₇S

Color and Shape: White To Off-White

Molecular weight: 541.71

Ref: TR-T009137