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CAS 2576-84-3

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Metoclopramide dihydrochloride

Description:
Metoclopramide dihydrochloride is a pharmaceutical compound primarily used as an antiemetic and gastroprokinetic agent. It is a derivative of procainamide and functions by blocking dopamine receptors in the central nervous system, which helps to alleviate nausea and vomiting. The dihydrochloride form indicates that the compound is a salt, enhancing its solubility in water, which is beneficial for its administration. Metoclopramide is often utilized in the treatment of conditions such as gastroparesis and postoperative nausea. Its chemical structure includes a benzamide moiety, contributing to its pharmacological activity. The compound is typically administered orally or via injection, and its effects can be observed relatively quickly. However, it is important to monitor for potential side effects, which may include drowsiness, fatigue, and, in rare cases, extrapyramidal symptoms due to its central nervous system activity. Overall, Metoclopramide dihydrochloride is a valuable medication in managing gastrointestinal disorders, but its use should be carefully considered in light of its side effect profile.
Formula:C14H22ClN3O2·2ClH
InChI:InChI=1S/C14H22ClN3O2.2ClH/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;;/h8-9H,4-7,16H2,1-3H3,(H,17,19);2*1H
InChI key:InChIKey=HPPDSFRJRMUHSC-UHFFFAOYSA-N
SMILES:C(NCCN(CC)CC)(=O)C1=C(OC)C=C(N)C(Cl)=C1.Cl
Synonyms:
  • o-Anisamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-, dihydrochloride
  • Metoclopramide dihydrochloride
  • Benzamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-, hydrochloride (1:2)
  • 2-Methoxy-5-chloroprocaine amide dihydrochloride
  • Benzamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-, dihydrochloride
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