CAS 257933-82-7

Pelitinib

Description:

Pelitinib is a small molecule inhibitor primarily designed to target the epidermal growth factor receptor (EGFR), which plays a crucial role in the proliferation and survival of cancer cells. It is classified as a tyrosine kinase inhibitor and is particularly relevant in the treatment of certain types of cancers, including non-small cell lung cancer. Pelitinib exhibits selectivity for the mutant forms of EGFR, which are often associated with resistance to other therapies. The compound's mechanism of action involves the inhibition of downstream signaling pathways that promote tumor growth and metastasis. In terms of its chemical properties, Pelitinib has a specific molecular structure that contributes to its biological activity, although detailed physicochemical properties such as solubility, stability, and bioavailability are essential for its therapeutic efficacy. Clinical studies have explored its potential benefits and side effects, contributing to the understanding of its role in targeted cancer therapy. As with any investigational drug, ongoing research continues to evaluate its effectiveness and safety profile in various patient populations.

Formula: C₂₄H₂₃ClFN₅O₂

InChI: InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+

InChI key: InChIKey=WVUNYSQLFKLYNI-AATRIKPKSA-N

SMILES: N(C=1C2=C(C=C(OCC)C(NC(/C=C/CN(C)C)=O)=C2)N=CC1C#N)C3=CC(Cl)=C(F)C=C3

Synonyms:

• (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
• (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide
• (E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
• 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-
• Ekb-569
• Way-Ekb 569
• Pelitinib

Pelitinib

CAS: 257933-82-7

Formula: C₂₄H₂₃ClFN₅O₂

Purity: >97.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 467.93

Ref: 3B-P2529

(E)-N-(4-((3-Chloro-4-Fluorophenyl)Amino)-3-Cyano-7-Ethoxyquinolin-6-Yl)-4-(Dimethylamino)But-2-Enamide

CAS: 257933-82-7

(E)-N-(4-((3-Chloro-4-Fluorophenyl)Amino)-3-Cyano-7-Ethoxyquinolin-6-Yl)-4-(Dimethylamino)But-2-Enamide

Purity: 98%

Molecular weight: 467.92g/mol

Ref: 54-PC108558

Pelitinib

CAS: 257933-82-7

Pelitinib

Purity: ≥95%

Molecular weight: 467.92g/mol

Ref: 54-BUP13326

Pelitinib

CAS: 257933-82-7

Formula: C₂₄H₂₃ClFN₅O₂

Purity: ≥ 98.0%

Color and Shape: White to beige or light-yellow powder to crystals

Molecular weight: 467.92

Ref: 7W-GP5214

Pelitinib

CAS: 257933-82-7

Pelitinib (EKB-569) (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).

Formula: C₂₄H₂₃ClFN₅O₂

Purity: 98.37% - 99.84%

Color and Shape: Off-White Solid

Molecular weight: 467.92

Ref: TM-T2327

Pelitinib

CAS: 257933-82-7

Purity: 98%

Molecular weight: 467.929992675781

Ref: 10-F794035

Pelitinib

CAS: 257933-82-7

EGFR tyrosine kinase inhibitor; pro-apoptotic; antiproliferative in cancer cells

Formula: C₂₄H₂₃ClFN₅O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 467.92 g/mol

Ref: 3D-FP32643

Pelitinib

Controlled Product

CAS: 257933-82-7

Applications A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer.
References Veronese, M., et al.: Br. J. Cancer, 92, 1846 (2005), Hofheinz, R., et al.: Onkologie, 29, 563 (2006), Meyerhardt, J., et al.: J. Clin. Oncol., 24, 1892 (2006), Hanauske, A., et al.: Clin. Cancer Res., 13, 523 (2007),

Formula: C₂₄H₂₃ClFN₅O₂

Color and Shape: Neat

Molecular weight: 467.92

Ref: TR-P218700