CAS 258516-87-9

Fospropofol disodium

Description:

Fospropofol disodium is a prodrug of propofol, primarily used as an anesthetic agent. It is characterized by its ability to be converted into propofol in the body, providing a means of sedation with a potentially smoother onset and offset of action compared to propofol itself. The substance is a white to off-white crystalline powder that is soluble in water, which facilitates its administration via intravenous injection. Fospropofol disodium is known for its rapid onset of sedation and a favorable safety profile, making it suitable for procedural sedation. Its pharmacokinetics involve metabolism primarily in the liver, where it is hydrolyzed to release propofol. The use of fospropofol disodium is associated with a lower incidence of pain on injection compared to propofol, although it may cause transient side effects such as paresthesia. As with any anesthetic, careful monitoring is essential during its use to manage potential respiratory depression and other adverse effects. Overall, fospropofol disodium represents an important option in the field of sedation and anesthesia.

Formula: C₁₃H₁₉Na₂O₅P

InChI: InChI=1/C13H21O5P.2Na/c1-9(2)11-6-5-7-12(10(3)4)13(11)17-8-18-19(14,15)16;;/h5-7,9-10H,8H2,1-4H3,(H2,14,15,16);;/q;2*+1/p-2

InChI key: InChIKey=CJQPTLNATSBIQV-UHFFFAOYSA-N

SMILES: O(COP(=O)(O)O)C1=C(C(C)C)C=CC=C1C(C)C.[Na]

Synonyms:

• Aqavan Injection
• Aquavan
• Aquavan injection
• Disodium [2,6-Bis(1-Methylethyl)Phenoxy]Methyl Phosphate
• Fospropofol Disodium (Aquavan)
• Gpi 15715
• Lusedra
• Methanol, (2,6-bis(1-methylethyl)phenoxy)-, dihydrogen phosphate, disodium salt
• Methanol, 1-[2,6-bis(1-methylethyl)phenoxy]-, 1-(dihydrogen phosphate), sodium salt (1:2)
• Pq-1002
• Unii-30868Ay0If
• [2,6-bis(1-Methylethyl)phenoxy]-Methanol dihydrogen phosphate disodiuM salt
• 1-[2,6-Bis(1-methylethyl)phenoxy]methanol phosphate disodium salt
• Fospropofol(disodium,[2,6-di(propan-2-yl)phenoxy]methyl phosphate)

Fospropofol Disodium Salt

CAS: 258516-87-9

Formula: C₁₃H₁₉O₅P·2Na

Molecular weight: 286.26 2*22.99

Ref: 4Z-F-215001

Aquavan

Controlled Product

CAS: 258516-87-9

Stability Hygroscopic
Applications Aquavan, more commonly known as Fospropofol Disodium, is a sedative/ hypnotic drug and a water-soluble prodrug of Propofol (P829750). Studies show that Fospropofol Disodium can have a protective effect on rat liver against ischemia-reperfusion injury.
References Campion, M.E., et al.: Drugs Today, 45, 567 (2009); Liu, Y., et al.: Sichuan Daxue Xuebao, Yixueban, 42, 231 (2011); Wang, H., et al.: Yiyao Daobao, 29, 1291 (2010); Xie, L., et al.: Mazui Yu Jianhu Luntan, 17, 348 (2010)

Formula: C₁₃H₁₉Na₂O₅P

Color and Shape: Neat

Molecular weight: 332.24

Ref: TR-A735445

Aquavan-d17

Controlled Product

CAS: 258516-87-9

Formula: C₁₃D₁₇H₂Na₂O₅P

Color and Shape: Neat

Molecular weight: 349.345

Ref: TR-A735447

Fospropofol disodium

Controlled Product

CAS: 258516-87-9

Fospropofol is a general anaesthetic drug used in the treatment of insomnia, agitation and anxiety. It is also used as an adjunct to anesthesia for certain procedures such as colonoscopy or gastroscopy. Fospropofol binds to voltage-gated potassium channels, increasing the duration of potassium channel opening, which leads to hyperpolarization of neurons and inhibition of neuronal firing. This inhibition leads to sedation and muscle relaxation. Fospropofol also binds with high affinity to GABA receptors, leading to increased chloride flux into neurons and hyperpolarization. This results in reduced levels of acetylcholine at synapses, which induces sleepiness. The binding affinity for GABA receptors is much higher than that for voltage-gated potassium channels, so it is thought that GABA receptor binding may be responsible for the sedative effects seen with fospropofol administration. Fospropofol disodium (also known as fosphenytoin sodium

Formula: C₁₃H₁₉Na₂O₅P

Purity: Min. 95%

Molecular weight: 334.26 g/mol

Ref: 3D-IKA51687