CAS 2589531-76-8

saruparib

Description:

Saruparib is a small molecule inhibitor primarily developed for the treatment of cancer, particularly in tumors with specific genetic mutations such as BRCA1 and BRCA2. It functions as a poly(ADP-ribose) polymerase (PARP) inhibitor, which interferes with the DNA repair mechanisms in cancer cells, leading to cell death. Saruparib is characterized by its ability to selectively target cancer cells that are deficient in homologous recombination repair, making it particularly effective in certain types of breast and ovarian cancers. The compound is administered orally and has been evaluated in clinical trials for its efficacy and safety profile. Its mechanism of action involves the inhibition of PARP enzymes, which play a crucial role in repairing single-strand breaks in DNA. By blocking this repair pathway, saruparib enhances the cytotoxic effects of DNA-damaging agents, thereby improving therapeutic outcomes in patients with specific genetic backgrounds. As with many targeted therapies, monitoring for potential side effects and interactions with other medications is essential during treatment.

Formula: C₂₂H₂₆N₆O₂

Synonyms:

• AZD-5305
• 5-[4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]-1-piperazinyl]-N-methylpicolinamide
• 2-Pyridinecarboxamide, 5-[4-[(7-ethyl-5,6-dihydro-6-oxo-1,5-naphthyridin-3-yl)methyl]-1-piperazinyl]-N-methyl-
• 5-{4-[(7-ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide

5-(4-((7-Ethyl-6-Oxo-5,6-Dihydro-1,5-Naphthyridin-3-Yl)Methyl)Piperazin-1-Yl)-N-Methylpicolinamide

CAS: 2589531-76-8

5-(4-((7-Ethyl-6-Oxo-5,6-Dihydro-1,5-Naphthyridin-3-Yl)Methyl)Piperazin-1-Yl)-N-Methylpicolinamide

Purity: 98%

Molecular weight: 406.48g/mol

Ref: 54-OR1023307

AZD5305

CAS: 2589531-76-8

AZD5305

Purity: ≥98%

Molecular weight: 406.48g/mol

Ref: 54-BUP07612

AZD5305

CAS: 2589531-76-8

AZD5305 is a potent, selective and oral active PARP inhibitor.

Formula: C₂₂H₂₆N₆O₂

Purity: 98.68% - 99.93%

Color and Shape: Solid

Molecular weight: 406.48

Ref: TM-T9165

AZD5305

CAS: 2589531-76-8

AZD5305 is an anticancer drug that targets protein kinases involved in cell cycle regulation and tumor growth. It acts as a potent inhibitor of several kinase pathways, including those related to apoptosis and cancer cell proliferation. AZD5305 has been shown to be effective against various types of cancer, including Chinese hamster ovary cells and human cancer cells. This medicinal compound is excreted primarily through urine, indicating its high bioavailability and potential for use in cancer therapy. The unique mechanism of action of AZD5305 makes it a promising candidate for the development of novel kinase inhibitors for the treatment of cancer.

Formula: C₂₂H₂₆N₆O₂

Purity: Min. 95%

Molecular weight: 406.5 g/mol

Ref: 3D-PDE53176