β-Catenin-IN-8, identified by its CAS number 259130-14-8, is a small molecule inhibitor that specifically targets the β-catenin pathway, which plays a crucial role in cell signaling and regulation of gene expression, particularly in the context of cancer and developmental biology. This compound is characterized by its ability to disrupt the interaction between β-catenin and its transcriptional co-activators, thereby inhibiting the Wnt/β-catenin signaling pathway. The inhibition of this pathway is significant in therapeutic contexts, especially for cancers where aberrant β-catenin activity is implicated. β-Catenin-IN-8 is typically studied in preclinical models to evaluate its efficacy and safety profile. Its chemical structure includes specific functional groups that contribute to its binding affinity and selectivity for β-catenin. As a research tool, it aids in understanding the biological functions of β-catenin and the potential for developing targeted therapies in diseases associated with its dysregulation.

β-catenin-IN-8

259130-14-8: β-Catenin-IN-8, identified by its CAS number 259130-14-8, is a small molecule inhibitor that specifically targets the β-catenin pathway, which plays a crucial role in cell signaling and regulation of gene expression, particularly in the context of cancer and developmental biology. This compound is characterized by its ability to disrupt the interaction between β-catenin and its transcriptional co-activators, thereby inhibiting the Wnt/β-catenin signaling pathway. The inhibition of this pathway is significant in therapeutic contexts, especially for cancers where aberrant β-catenin activity is implicated. β-Catenin-IN-8 is typically studied in preclinical models to evaluate its efficacy and safety profile. Its chemical structure includes specific functional groups that contribute to its binding affinity and selectivity for β-catenin. As a research tool, it aids in understanding the biological functions of β-catenin and the potential for developing targeted therapies in diseases associated with its dysregulation.

<p>β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.</p>

CAS 259130-14-8

β-catenin-IN-8

β-catenin-IN-8

Ref: TM-T201581