CAS 26016-99-9: Fosfomycin sodium
Description:Fosfomycin sodium is an antibiotic used primarily for the treatment of urinary tract infections. It is a phosphonic acid derivative that acts by inhibiting bacterial cell wall synthesis, specifically targeting the enzyme MurA, which is crucial for peptidoglycan formation. This mechanism makes it effective against a broad spectrum of Gram-positive and Gram-negative bacteria. Fosfomycin sodium is typically administered as a prodrug, which is converted to its active form in the body. It is characterized by its high solubility in water, allowing for easy administration and absorption. The compound is generally well-tolerated, with a low incidence of side effects, although some patients may experience gastrointestinal disturbances or allergic reactions. Its pharmacokinetics include rapid absorption and excretion, with a relatively short half-life, necessitating careful dosing. Fosfomycin sodium is often used in cases of uncomplicated cystitis and is notable for its ability to penetrate biofilms, making it a valuable option in treating resistant infections.
Formula:C3H7O4P·2Na
InChI:InChI=1S/C3H7O4P.2Na/c1-2-3(7-2)8(4,5)6;;/h2-3H,1H3,(H2,4,5,6);;/t2-,3+;;/m0../s1
InChI key:InChIKey=XKMSQWKOGZTAQM-JSTPYPERSA-N
SMILES:[Na].O=P(O)(O)C1OC1C
- Synonyms:
- (3-Methyloxiran-2-Yl)Phosphonic Acid
- Disodium fosfomycin
- Disodium phosphonomycin
- FOM-Na
- Forocyle S
- Fosfocin
- Fosfomycin disodium
- Fosfomycin disodium salt
- Fosfomycin sodium
- Fosfomycin sodium salt
- See more synonyms
- Fosmicin S
- Levo-phosphonomycin disodium salt
- NSC 136017
- Phosphomycin Disodium
- Phosphomycin sodium
- Phosphonic acid, (1,2-epoxypropyl)-, disodium salt, (1R,2S)-(-)-
- Phosphonic acid, (3-methyloxiranyl)-, disodium salt, (2R-cis)-
- Phosphonic acid, P-[(2R,3S)-3-methyl-2-oxiranyl]-, sodium salt (1:2)
- Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, disodium salt
- Phosphonomycin disodium salt
- Phosphonomycin sodium
- Sodium fosfomycin
- disodium [(2R,3S)-3-methyloxiran-2-yl]phosphonate
