CAS 26048-05-5

beauvericin

Description:

Beauvericin is a cyclic hexadepsipeptide mycotoxin produced by various species of fungi, particularly those in the Beauveria and Fusarium genera. It is characterized by its unique structure, which consists of alternating amino acid and hydroxy acid residues, forming a cyclic arrangement. Beauvericin exhibits a range of biological activities, including cytotoxicity and immunosuppressive effects, making it of interest in both toxicology and pharmacology. It has been shown to interfere with cellular processes, such as apoptosis and ion transport, particularly affecting potassium channels. This compound is also notable for its potential as a biopesticide, given its antifungal properties. However, its presence in food and feed products raises concerns regarding safety and regulatory limits, as it can pose health risks to humans and animals. Analytical methods, such as liquid chromatography coupled with mass spectrometry, are commonly employed to detect and quantify beauvericin in various matrices. Overall, while beauvericin has potential applications, its toxicological profile necessitates careful handling and monitoring.

Formula: C₄₅H₅₇N₃O₉

InChI: InChI=1/C45H57N3O9/c1-28(2)37-40(49)46(7)35(26-32-21-15-11-16-22-32)44(53)56-39(30(5)6)42(51)48(9)36(27-33-23-17-12-18-24-33)45(54)57-38(29(3)4)41(50)47(8)34(43(52)55-37)25-31-19-13-10-14-20-31/h10-24,28-30,34-39H,25-27H2,1-9H3/t34-,35-,36-,37+,38+,39+/m0/s1

Synonyms:

• Cyclo(-D-.alpha.-hydroxyisovaleryl-N-Me-Phe)3
• (3S,6R,9S,12R,15S,18R)-3,9,15-tribenzyl-4,10,16-trimethyl-6,12,18-tris(1-methylethyl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

Beauvericin

CAS: 26048-05-5

Beauvericin is a member of the enniatin family of antibiotics. Activity against Gram-positive bacteria and mycobacteria has been demonstrated. The cyclic depsipeptide forms complexes with alkali metal and alkaline earth metal ions. Additionally, beauvericin was reported to be toxic to brine shrimps and mosquito larvae.

Formula: C₄₅H₅₇N₃O₉

Purity: 99.5%

Color and Shape: White

Molecular weight: 783.96

Ref: 01-4013628

CYCLO[(2R)-2-HYDROXY-3-METHYLBUTANOYL-N-METHYL-L-PHENYLALANYL-(2R)-2-HYDROXY-3-METHYLBUTANOYL-N-METHYL-L-PHENYLALANYL-(2R)-2-HYDROXY-3-METHYLBUTANOYL-N-METHYL-L-PHENYLALANYL]

CAS: 26048-05-5

Formula: C₄₅H₅₇N₃O₉

Purity: 97%

Color and Shape: Solid

Molecular weight: 783.9488

Ref: IN-DA002RIL

Beauvericin

CAS: 26048-05-5

Beauvericin

Formula: C₄₅H₅₇N₃O₉

Purity: 97%

Color and Shape: white powder

Molecular weight: 783.95g/mol

Ref: 54-BIB1600

Beauvericin

CAS: 26048-05-5

Beauvericin, a Fusarium mycotoxin, inhibits acyl-CoA:cholesterol acyltransferase (ACAT) in rat liver microsomal enzyme assays with an IC50 value of 3 μM.

Formula: C₄₅H₅₇N₃O₉

Purity: ≥98%

Color and Shape: Solid

Molecular weight: 783.95

Ref: TM-T14523

Beauvericin

Controlled Product

CAS: 26048-05-5

Formula: C₄₅H₅₇N₃O₉

Color and Shape: Neat

Molecular weight: 783.95

Ref: 04-C10428500

Beauvericin

CAS: 26048-05-5

Formula: C₄₅H₅₇N₃O₉

Purity: 95%~99%

Molecular weight: 783.963

Ref: BP-BP5287

Beauvericin

CAS: 26048-05-5

Formula: C₄₅H₅₇N₃O₉

Purity: ≥ 97.0%

Color and Shape: White to off-white powder

Molecular weight: 783.96

Ref: 7W-GA8043

Beauvericin

CAS: 26048-05-5

Formula: C₄₅H₅₇N₃O₉

Molecular weight: 783.96

Ref: 4Z-B-228001

Beauvericin

CAS: 26048-05-5

Applications Beauvericin is a toxic depsipeptide with antibiotic and insecticidal effects.
References Lee, H., et al.: J. Microbiol., Biotechnol., 18, 138 (2008), Moretti, A., et al.: Int. J. Food Microbiol., 127, 312 (2008), Jestoi, M., et al.: Food Chem., 115, 1120 (2009), Santini, A., et al.: Anal. Bioanal. Chem., 395, 1253 (2009),

Formula: C₄₅H₅₇N₃O₉

Color and Shape: Off White Crystalline

Molecular weight: 783.95

Ref: TR-B119230

Beauvericin

CAS: 26048-05-5

Beauvericin is a cyclic peptide that is isolated from the fungus Fusarium. It has been shown to have antimicrobial activity against bacteria, as well as a variety of other biological properties. Beauvericin has been shown to inhibit mitochondrial membrane potential and induce toxicity in some animal models. Beauvericin also inhibits protein synthesis and causes cell death by inhibiting DNA polymerase activity. This compound is active against cancer cells, including HL-60 cells, which are derived from human lymphocytes and are used as a model for leukemia. Beauvericin can be extracted from an ETOA extract of the fungus Fusarium oxysporum; this extract has shown anti-cancer effects in vitro assays.

Formula: C₄₅H₅₇N₃O₉

Purity: Min. 95%

Molecular weight: 783.95 g/mol

Ref: 3D-FB18149